Neuropediatrics 2010; 41(4): 157-162
DOI: 10.1055/s-0030-1267155
Review Article

© Georg Thieme Verlag KG Stuttgart · New York

A Practical Guide to Pediatric Multiple Sclerosis

P. Huppke1 , J. Gärtner1
  • 1Department of Pediatrics and Pediatric Neurology, Georg August University, Göttingen, Germany
Further Information

Publication History

received 01.03.2010

accepted 06.09.2010

Publication Date:
17 November 2010 (online)

Abstract

During the past 10 years much knowledge has been gained about multiple sclerosis in the pediatric population. This article summarizes the information relevant to the neurologist and pediatric neurologist concerning the diagnosis, differential diagnosis and therapy for pediatric MS.

References

  • 1 Banwell B, Ghezzi A, Bar-Or A. et al . Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions.  Lancet neurology. 2007;  6 887-902
  • 2 Banwell B, Kennedy J, Sadovnick D. et al . Incidence of acquired demyelination of the CNS in Canadian children.  Neurology. 2009;  72 232-239
  • 3 Banwell B, Krupp L, Kennedy J. et al . Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study.  Lancet neurology. 2007;  6 773-781
  • 4 Banwell B, Reder AT, Krupp L. et al . Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis.  Neurology. 2006;  66 472-476
  • 5 Banwell B, Shroff M, Ness JM. et al . MRI features of pediatric multiple sclerosis.  Neurology. 2007;  68 S46-53
  • 6 Banwell B, Tenembaum S, Lennon VA. et al . Neuromyelitis optica-IgG in childhood inflammatory demyelinating CNS disorders.  Neurology. 2008;  70 344-352
  • 7 Boiko A, Vorobeychik G, Paty D. et al . Early onset multiple sclerosis: a longitudinal study.  Neurology. 2002;  59 1006-1010
  • 8 Bonhomme GR, Waldman AT, Balcer LJ. et al . Pediatric optic neuritis: brain MRI abnormalities and risk of multiple sclerosis.  Neurology. 2009;  72 881-885
  • 9 Borriello G, Prosperini L, Luchetti A. et al . Natalizumab treatment in pediatric multiple sclerosis: A case report.  Eur J Paediatr Neurol. 2008; 
  • 10 Chabas D, Castillo-Trivino T, Mowry EM. et al . Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype?.  Neurology. 2008;  71 1090-1093
  • 11 Chitnis T, Glanz B, Jaffin S. et al . Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States.  Multiple sclerosis (Houndmills, Basingstoke, England). 2009;  15 627-631
  • 12 Cohen BA, Khan O, Jeffery DR. et al . Identifying and treating patients with suboptimal responses.  Neurology. 2004;  63 S33-S40
  • 13 Ghezzi A. Immunomodulatory treatment of early onset multiple sclerosis: results of an Italian Co-operative Study.  Neurol Sci. 2005;  26 (S 04) S183-S186
  • 14 Ghezzi A, Amato MP, Capobianco M. et al . Disease-modifying drugs in childhood-juvenile multiple sclerosis: results of an Italian co-operative study.  Multiple sclerosis (Houndmills, Basingstoke, England). 2005;  11 420-424
  • 15 Ghezzi A, Banwell B, Boyko A. et al . The management of multiple sclerosis in children: a European view.  Multiple sclerosis (Houndmills, Basingstoke, England). 2010; 
  • 16 Ghezzi A, Deplano V, Faroni J. et al . Multiple sclerosis in childhood: clinical features of 149 cases.  Multiple sclerosis (Houndmills, Basingstoke, England). 1997;  3 43-46
  • 17 Hahn JS, Pohl D, Rensel M. et al . Differential diagnosis and evaluation in pediatric multiple sclerosis.  Neurology. 2007;  68 S13-S22
  • 18 Huppke P, Stark W, Zurcher C. et al . Natalizumab use in pediatric multiple sclerosis.  Archives of neurology. 2008;  65 1655-1658
  • 19 Kornek B, Bernert G, Balassy C. et al . Glatiramer acetate treatment in patients with childhood and juvenile onset multiple sclerosis.  Neuropediatrics. 2003;  34 120-126
  • 20 Kriss A, Francis DA, Cuendet F. et al . Recovery after optic neuritis in childhood.  Journal of neurology, neurosurgery, and psychiatry. 1988;  51 1253-1258
  • 21 Krupp LB, Banwell B, Tenembaum S. Consensus definitions proposed for pediatric multiple sclerosis and related disorders.  Neurology. 2007;  68 S7-S12
  • 22 Krupp LB, Macallister WS. Treatment of Pediatric Multiple Sclerosis.  Current treatment options in neurology. 2005;  7 191-199
  • 23 Kuker W. Cerebral vasculitis: imaging signs revisited.  Neuroradiology. 2007;  49 471-479
  • 24 Lucchinetti CF, Kiers L, O’Duffy A. et al . Risk factors for developing multiple sclerosis after childhood optic neuritis.  Neurology. 1997;  49 1413-1418
  • 25 Makhani N, Gorman MP, Branson HM. et al . Cyclophosphamide therapy in pediatric multiple sclerosis.  Neurology. 2009;  72 2076-2082
  • 26 McAdam LC, Blaser SI, Banwell BL. Pediatric tumefactive demyelination: case series and review of the literature.  Pediatric neurology. 2002;  26 18-25
  • 27 McDonald WI, Compston A, Edan G. et al . Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis.  Annals of neurology. 2001;  50 121-127
  • 28 McLean BN, Luxton RW, Thompson EJ. A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index.  A comparison and diagnostic applications. Brain. 1990;  113 (Pt 5) 1269-1289
  • 29 Mikaeloff Y, Adamsbaum C, Husson B. et al . MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood.  Brain. 2004;  127 1942-1947
  • 30 Mikaeloff Y, Suissa S, Vallee L. et al . First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability.  The Journal of pediatrics. 2004;  144 246-252
  • 31 Neuteboom RF, Boon M, Catsman Berrevoets CE. et al . Prognostic factors after a first attack of inflammatory CNS demyelination in children.  Neurology. 2008;  71 967-973
  • 32 Pittock SJ, Lennon VA, Krecke K. et al . Brain abnormalities in neuromyelitis optica.  Archives of neurology. 2006;  63 390-396
  • 33 Pohl D, Rostasy K, Gartner J. et al . Treatment of early onset multiple sclerosis with subcutaneous interferon beta-1a.  Neurology. 2005;  64 888-890
  • 34 Pohl D, Rostasy K, Reiber H. et al . CSF characteristics in early-onset multiple sclerosis.  Neurology. 2004;  63 1966-1967
  • 35 Pohl D, Rostasy K, Treiber-Held S. et al . Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials.  The Journal of pediatrics. 2006;  149 125-127
  • 36 Pohl D, Waubant E, Banwell B. et al . Treatment of pediatric multiple sclerosis and variants.  Neurology. 2007;  68 S54-S65
  • 37 Polman CH, Reingold SC, Edan G. et al . Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”.  Annals of neurology. 2005;  58 840-846
  • 38 Renoux C, Vukusic S, Mikaeloff Y. et al . Natural history of multiple sclerosis with childhood onset.  The New England journal of medicine. 2007;  356 2603-2613
  • 39 Riikonen R, Donner M, Erkkila H. Optic neuritis in children and its relationship to multiple sclerosis: a clinical study of 21 children.  Developmental medicine and child neurology. 1988;  30 349-359
  • 40 Sellner J, Luthi N, Buhler R. et al . Acute partial transverse myelitis: risk factors for conversion to multiple sclerosis.  Eur J Neurol. 2008;  15 398-405
  • 41 Stark W, Huppke P, Gartner J. Paediatric multiple sclerosis: the experience of the German Centre for Multiple Sclerosis in Childhood and Adolescence.  Journal of neurology. 2008;  255 (S 06) 119-122
  • 42 Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients.  Neurology. 2002;  59 1224-1231
  • 43 Tenembaum S, Chitnis T, Ness J. et al . Acute disseminated encephalomyelitis.  Neurology. 2007;  68 S23-S36
  • 44 Tenembaum SN, Segura MJ. Interferon beta-1a treatment in childhood and juvenile-onset multiple sclerosis.  Neurology. 2006;  67 511-513
  • 45 Waubant E, Chabas D. Pediatric multiple sclerosis.  Current treatment options in neurology. 2009;  11 203-210
  • 46 Waubant E, Chabas D, Okuda DT. et al . Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs. adults.  Archives of neurology. 2009;  66 967-971
  • 47 Waubant E, Hietpas J, Stewart T. et al . Interferon beta-1a in children with multiple sclerosis is well tolerated.  Neuropediatrics. 2001;  32 211-213
  • 48 Wingerchuk DM, Hogancamp WF, O’Brien PC. et al . The clinical course of neuromyelitis optica (Devic's syndrome).  Neurology. 1999;  53 1107-1114
  • 49 Yeh EA, Chitnis T, Krupp L. et al . Pediatric multiple sclerosis.  Nat Rev Neurol. 2009;  5 621-631

Correspondence

Peter HuppkeMD 

Department of Pediatrics and

Pediatric Neurology

Georg August University

Faculty of Medicine

Robert-Koch-Straße 40

37075 Göttingen

Germany

Phone: +49/551/396 210

Fax: +49/551/396 252

Email: phuppke@med.uni-goettingen.de

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