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Horm Metab Res 2011; 43(5): 343-348
DOI: 10.1055/s-0031-1271778
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Weight Loss Improves Endothelial Function Independently of ADMA Reduction in Severe Obesity

G. Rudofsky1 , E. Roeder1 , 2 , T. Merle1 , M. Hildebrand1 , P. P. Nawroth1 , C. Wolfrum2
  • 1Department of Endocrinology and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
  • 2Swiss Federal Institute of Technology, Institute of Food Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
Further Information

Publication History

received 22.11.2010

accepted 27.01.2011

Publication Date:
01 March 2011 (online)

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Abstract

This prospective study was performed in order to establish whether improvement of endothelial function after weight reduction can be explained by a decrease of elevated asymmetric dimethyl arginine (ADMA), an inhibitor of endogenous NO-synthase (eNOS). Therefore, 21 obese subjects (BMI: 41.1±6.4 kg/m2) were studied at baseline and after 12 weeks of weight reduction with a very low calorie diet. Biochemical and clinical parameters of endothelial function were assessed before and after weight loss. Biochemical parameters were determined by measurement of ADMA and soluble intercellular adhesion molecule (sICAM). Clinical parameters were assessed by pulse wave analysis (PWA). Weight intervention resulted in a 21.4±6.8 kg reduction of body weight from 119.7±12.8 kg at study start to 98.3±11.6 kg at study end (p<0.001). Accordingly, biochemical markers improved under weight reduction (ADMA from 0.47±0.07 mmol/l to 0.42±0.08 mmol/l; p=0.002; ICAM from 276±42 ng/ml to 236±29 ng/ml; p<0.001). Further, clinical parameters of functional endothelial function improved with an increase of deltaRI after salbutamol inhalation from −1% before to −9% after weight reduction (p=0.02). Interestingly, improvement of endothelial function correlated with improved HOMA index only (r=−0.60, p=0.04) but not with reduced ADMA levels, improved hypertension or reduced body weight. In conclusion, weight reduction with a very low calorie diet improves endothelial function measured by pulse wave velocity. The missing correlation with ADMA suggests possible further mechanisms underlying this observed effect, for example, improvement of insulin resistance.

Key words

weight loss - pulse wave analysis - ADMA - sICAM - obesity - endothelial dysfunction

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Correspondence

G. RudofskyMD 

Department of Medicine I and

Clinical Chemistry

Im Neuenheimer Feld 410

69120 Heidelberg

Germany

Phone: +49/6221/563 86 20

Fax: +49/6221/565 793

Email: gottfried_rudofsky@med.uni-heidelberg.de

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