Abstract
An 11-year-old boy with attention deficit/hyperactivity disorder (ADHD) presented
with visual hallucinations several years after starting methylphenidate (MPH). The
hallucinations resolved upon discontinuation of the drug. Reports of toxic hallucinosis
during treatment with MPH are rare. Although the pathogenetic mechanism is unclear,
the occurrence of hallucinations may be explained by a chronic increase in synaptic
dopamine. Clinicians should be aware of this possible rare adverse manifestation occurring
at therapeutic doses.
Key words
methylphenidate - hallucinations - ADHD
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Correspondence
Paolo Curatolo
Department of Neuroscience
Pediatric Neurology Unit
Tor Vergata University of Rome
via Montpellier 1
00133 Rome
Italy
Phone: + 39/06/41400 129
Fax: + 39/06/41400 343
Email: curatolo@uniroma2.it