A Nested Case-Control Study of First-Trimester Maternal Vitamin D Status and Risk for Spontaneous Preterm Birth

Arthur M Baker; Sina Haeri; Carlos A Camargo; Alison M Stuebe; Kim A Boggess

doi:10.1055/s-0031-1276731

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2011; 28(9): 667-672
DOI: 10.1055/s-0031-1276731

A Nested Case-Control Study of First-Trimester Maternal Vitamin D Status and Risk for Spontaneous Preterm Birth

Arthur M. Baker¹ , Sina Haeri¹ , Carlos A. Camargo³ ^, ⁴ , Alison M. Stuebe¹ ^, ² , Kim A. Boggess¹

¹Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina
²Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina
³Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts
⁴Center for D-receptor Activation Research, Massachusetts General Hospital, Boston, Massachusetts

Abstract

ABSTRACT

We assessed if first-trimester vitamin D deficiency is more prevalent in women who experienced a spontaneous preterm birth compared with women who delivered at term. We conducted a nested case-control study of pregnant women who had previously given blood for first-trimester combined screening for trisomy 21 and subsequently delivered at a tertiary hospital between November 2004 and July 2009. From an overall cohort of 4225 women, 40 cases of spontaneous preterm birth (≥23⁰/₇ and ≤34⁶/₇ weeks) were matched by race/ethnicity with 120 women delivering at term (≥37⁰/₇ weeks) with uncomplicated pregnancies. Banked maternal serum was used to measure maternal 25-hydroxyvitamin D [25(OH)D]. The prevalence of first-trimester maternal vitamin D deficiency [25(OH)D <50 nmol/L] was comparable among women who subsequently delivered preterm compared with controls (7.5% versus 6.7%, p = 0.90). The median 25(OH)D level for all subjects was 89 nmol/L (interquartile range, 73 to 106 nmol/L). Seventy-three percent (117/160) of the cohort had sufficient vitamin D levels [25(OH)D ≥75 nmol/L]. In a cohort of pregnant women with mostly sufficient levels of first-trimester serum 25(OH)D, vitamin D deficiency was not associated with spontaneous preterm birth.

KEYWORDS

Preterm birth - vitamin D - 25-hydroxyvitamin D

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Referenzen

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Arthur M BakerM.D.

Department of Obstetrics and Gynecology, 3010 Old Clinic Building

CB#7516, University of North Carolina, Chapel Hill, NC 27599-7516

eMail: abaker2@med.unc.edu