Neuropediatrics 2011; 42(02): 82-85
DOI: 10.1055/s-0031-1279784
Short Communication
Georg Thieme Verlag Stuttgart · New York

Leukoencephalopathy with Vanishing White Matter: Serial MRI of the Brain and Spinal Cord including Diffusion Tensor Imaging

A. Meoded
1   Division of Pediatric Radiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
,
A. Poretti
1   Division of Pediatric Radiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
2   Department of Pediatric Neurology, University Children′s Hospital, Zurich, Switzerland
,
S. Yoshida
3   Laboratory of Brain Anatomical MRI, Russell H. Morgan, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MH, USA
,
T.A.G.M. Huisman
1   Division of Pediatric Radiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
› Author Affiliations
Further Information

Publication History

received 10 January 2011

accepted: 14 May 2011

Publication Date:
14 June 2011 (online)

Abstract

Vanishing white matter disease (VWM) is one of the most frequent inherited childhood white matter disorders. We present the brain and spinal cord disease progression on serial conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in a 4-year-old boy. Consecutive MRI examinations demonstrated a progression of the signal abnormalities in the cerebral white matter. Globally, apparent diffusion coefficient (ADC) values as well as axial and radial diffusivity increased over time, while fractional anisotropy (FA) values decreased. Involvement of the cervical posterior spinal tracts and mild global spinal cord atrophy was found. In conclusion, serial MRI and DTI studies may help to better understand the selective injury of the myelin and axons in VWM disease. These data may help in monitoring disease progression. Our data also show that complete neuroimaging work-up in VWM should also include the spinal cord.

 
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