New Pyrones from the Mangrove Endophytic Fungus Pestalotiopsis sp

Pestalotiopsis is generally found as endophytes of tropical plants and as prolific producers of structurally unusal natural products [1]. Our previous chemical investigations on fungus species Pestalotiopsis JCM2A4 isolated from the Chinese Mangrove plant Rhizophora mucronata Lam. have led to the isolation of a series of natural products and yielded over twenty different compounds with seventeen of them being new natural products including chromones, cytosporones and coumarins [2–3]. Following cultivation of the fungus now yielded eight new pyrone derivatives (1) as well as a known compound. The structures of all compounds were unambiguously established from their spectroscopic data, that included HR-ESIMS and 1- and 2-dimensional NMR spectroscopy, and by comparison with the literature [4]. Our findings proved endophyte genus Pestalotiopsis to be particularly productive.

Figure 1: Structure of pyrone

Acknowledgement: Financial support by grants of Hainan University Youth Foundation (qnjj1005) and Dr. Research Starting Found (kyqd1066) are gratefully acknowledged.

References: 1. Xu J et al. (2010) Fungal Divers 44:15–31. 2. Xu J et al. (2009)J Nat Prod 72: 662–665. 3. Xu J et al. (2009) Bioorg Med Chem 17: 7362–7367. 4. Xu J et al. (2011) Tetrahedron Lett 52: 21–25.