Acute Lymphoblastic Leukemia in a 10-Year-Old Boy With Cystic Fibrosis – Improvement of Pulmonary Function During Chemotherapy in spite of Intermittent Pseudomonas Aeruginosa Colonisation

C. Dopfer; K. Kentouche; B. Gruhn; R. Dopfer; S. Becker; H.-J. Mentzel; J. F. Beck; J. G. Mainz

doi:10.1055/s-0031-1285880

Klin Padiatr 2011; 223(06): 368-369
DOI: 10.1055/s-0031-1285880

Pictorial Essay

Acute Lymphoblastic Leukemia in a 10-Year-Old Boy With Cystic Fibrosis – Improvement of Pulmonary Function During Chemotherapy in spite of Intermittent Pseudomonas Aeruginosa Colonisation

Akute lymphoblastische Leukämie bei einem 10-jährigen Jungen mit zystischer Fibrose – Verbesserung der Lungenfunktion während Chemotherapie trotz intermittierender Pseudomonas-aeruginosa-Besiedlung

Authors

C. Dopfer

¹Department of Pediatrics, Cystic Fibrosis Centre, Jena University Hospital, Germany
K. Kentouche

²Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
B. Gruhn

²Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
R. Dopfer

³ Rehabilitation Hospital, Villingen-Schwenningen, Tannheim gGmbH, Germany
S. Becker

²Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
H.-J. Mentzel

⁴Pediatric Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Germany
J. F. Beck

²Department of Pediatrics, Hematology and Oncology, Jena University Hospital, Germany
J. G. Mainz

¹Department of Pediatrics, Cystic Fibrosis Centre, Jena University Hospital, Germany

Abstract

Background

Multiorgan involvement in cystic fibrosis (CF), including chronic airway infection with pathogens like Pseudomonas aeruginosa, is a critical risk factor in patients with malignancy during aggressive immunosuppressive therapy, and was therefore formerly associated with high mortality rates. A 10 year old boy with CF and acute lymphoblastic leukemia (ALL) underwent induction and reinduction treatment without severe infectious complications whereas lung function improved.

Key words

cystic fibrosis - leukemia - pulmonary function - osteopenia - cerebral venous thrombosis - liver toxicity

Schlüsselwörter

zystische Fibrose - Leukämie - Lungenfunktion - Osteopenie - Sinusvenenthrombose - Lebertoxizität

Full Text

References

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