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Horm Metab Res 2011; 43(10): 720-722
DOI: 10.1055/s-0031-1286310
Humans, Clinical
Georg Thieme Verlag KG Stuttgart · New York

Annual Change in Insulin Sensitivity

F. Isken
1   Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
2   Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany
†   Deceased
,
U. Abraham
3   Laboratory of Chronobiology, Department of Medical Immunology, Charité-University-Medicine Berlin, Berlin, Germany
,
M. O. Weickert
1   Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
4   Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, UK and Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, UK
,
F. Keyhani-Nejad
1   Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
2   Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany
,
A. M. Arafat
2   Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany
,
J. Spranger
1   Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
2   Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany
,
A.F. H. Pfeiffer
1   Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
2   Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany
,
M. Möhlig
1   Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
2   Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany
› Author Affiliations
Further Information

Publication History

received 26 March 2011

accepted 06 August 2011

Publication Date:
19 September 2011 (online)

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Abstract

The incidence of both type 2 diabetes and cardiac events is reported to be higher during winter, indicating a putative annual periodic change in insulin sensitivity (IS). Annual differences in IS – quantified as HOMA-%S and Matsuda-Sensitivity Index – were analyzed using a cosine wave-fitting algorithm in a cross-sectional study group including 2 385 participants. Additionally, semi-annual differences in IS were compared. We found periodicity for HOMA-%S and Matsuda-Sensitivity Index (p=0.02 or 0.006), which was strengthened after restriction to participants without diabetes (p=0.009 or 0.004). The rhythm amplitude of 0.08 indicated moderate changes in IS throughout the year. IS was significantly higher when participants were enrolled during the second vs. the first half of the year (HOMA-%S 112.0±3.0% vs. 97.4±2.4%, p<0.001). The impact of the half-year on IS, which remained significant after adjustment for confounders, was again moderate and explained only 0.5% of the variation. IS showed a significant moderate annual periodicity, which may affect the interpretation of studies reporting small changes in IS.

Key words

insulin resistance - insulin sensitivity - annual - HOMA
 

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