Synthesis of Functionalized
3,4-Diarylbenzophenones and 2,4-Diarylbenzophenones by Site-Selective
Suzuki and Sonogashira Cross-Coupling Reactions of Bis(triflates)
of 3,4- and 2,4-Dihydroxybenzophenone

Rasheed Ahmed Khera; Muhammad Nawaz; Holger Feist; Alexander Villinger; Peter Langer

doi:10.1055/s-0031-1289649

PAPER

Synthesis of Functionalized 3,4-Diarylbenzophenones and 2,4-Diarylbenzophenones by Site-Selective Suzuki and Sonogashira Cross-Coupling Reactions of Bis(triflates) of 3,4- and 2,4-Dihydroxybenzophenone

Rasheed Ahmed Khera^a,b, Muhammad Nawaz^a,c, Holger Feist^a, Alexander Villinger^a, Peter Langer*^a,d
^a Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
Fax: +49(381)4986412; e-Mail: peter.langer@uni-rostock.de;
^b Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad, Pakistan
^c Department of Chemistry, Comsats Institute of Information Technology, Campus Abbottabad, Abbottabad, Pakistan
^d Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany

Abstract

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Abstract

Palladium(0)-catalyzed Suzuki and Sonogashira cross-coupling reactions of the bis(triflates) of 2,4- and 3,4-dihydroxybenzophenone afforded 2,4- and 3,4-diarylbenzophenones, respectively. The reactions proceeded with very good site-selectivity in favor of position 4.

Key words

benzophenone - cross-coupling - palladium - site-selectivity - Suzuki reaction - Sonogashira reaction

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References

Authors R.A.K. and M.N. contributed equally to this manuscript.

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