Synthesis, Table of Contents Synthesis 2012; 44(14): 2277-2286DOI: 10.1055/s-0031-1289783 paper © Georg Thieme Verlag Stuttgart · New YorkStudies toward Oxyacetamide-Linked RNA Analogues: Synthesis and Conformation of a Modified Dinucleoside Authors Author Affiliations Amit M. Jabgunde a Garware Research Center, Department of Chemistry, University of Pune, Pune 411 007, India Sachin D. Yeole a Garware Research Center, Department of Chemistry, University of Pune, Pune 411 007, India b Department of Chemistry, I.I.T. Kanpur, Kanpur 208016, India, Fax: +91(2025691728 Email: ddd@chem.unipune.ac.in Shrihari P. Sanap a Garware Research Center, Department of Chemistry, University of Pune, Pune 411 007, India Shridhar R. Gadre b Department of Chemistry, I.I.T. Kanpur, Kanpur 208016, India, Fax: +91(2025691728 Email: ddd@chem.unipune.ac.in Dilip D. Dhavale* a Garware Research Center, Department of Chemistry, University of Pune, Pune 411 007, India Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Dedicated to Prof. M. S. Wadia on the occasion of his 75th birthday Abstract A new oxyacetamide-modified dinucleoside with 5′-(S) chirality, a hydrophobic 5′-C-(2-methoxyethyl) group, and a 2′-O-methyl group was synthesized from d-glucose. This dinucleoside showed a helical structure based on CD and NMR spectroscopy. The sugar puckering at the 5′ and 3′ ends were found to be ‘S’- and ‘N’-types, respectively. These results were substantiated by ab initio density functional theory. Key words Key wordsmodified dinucleoside - circular dichroism - oxyacetamide backbone - antisense agents - carbohydrates Full Text References References 1a Uhlmann E, Peyman A. Chem. Rev. 1990; 90: 543 1b Kumar VA. Eur. J. Org. Chem. 2002; 2021 1c Kaur H, Babu BR, Maiti S. Chem. 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