Synthesis 2012; 44(10): 1556-1558
DOI: 10.1055/s-0031-1290947
short paper
© Georg Thieme Verlag Stuttgart · New York

A Practical Synthesis of Alendronate Sodium through Counterattack Reaction

Masahiko Seki*
Mitsubishi Tanabe Pharma Corporation, 2-6-18, Kitahama, Chuo-ku, Osaka 541-8505, Japan, Email: seki.masahiko@mm.mt-pharma.co.jp
› Author Affiliations
Further Information

Publication History

Received: 13 February 2012

Accepted after revision: 14 March 2012

Publication Date:
19 April 2012 (online)


Abstract

An efficient synthesis of alendronate sodium, an osteoporosis drug, has been developed through ‘counterattack reaction’ involving treatment of the respective acyl phosphonate with (MeO)3P and TMSBr followed by deblocking with aqueous HCl.

 
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