Synlett 2012; 23(10): 1446-1458
DOI: 10.1055/s-0031-1290967
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© Georg Thieme Verlag Stuttgart · New York

Method in the Madness – Methodology from Total Synthesis

Rebecca H. Pouwer
a  Eskitis Insitute for Cell and Molecular Therapies, Griffith University, Don Young Road, Nathan, QLD, 4111, Australia
,
Craig M. Williams*
b  School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, 4111, Australia, Fax: +61 7 33 65 42 99   Email: c.williams3@uq.edu.au
› Author Affiliations
Further Information

Publication History

Received: 17 December 2011

Accepted after revision: 11 January 2012

Publication Date:
29 May 2012 (online)


Abstract

A review surveying the synthetic methodology developed by the Williams group over the last ten years, driven by natural product total synthesis, is presented. An underlying theme over this time has been the reliance on physical organic chemistry, organometallics and the cyclohexane ring system.

1 Introduction

2 Morita–Baylis–Hilman (MBH) Reaction

3 2-Iodoxybenzoic Acid (IBX)

4 Wittig Reagents

5 cis-Alkenes for 6π-Electrocyclisations

6 Ketal-Claisen Rearrangements

7 Silver(I) Acetylides

8 Photochemistry

9 Acyl Anion Equivalents

10 Conclusion

 
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