Synlett 2012; 23(10): 1511-1515
DOI: 10.1055/s-0031-1291014
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 1,3-Disubstituted Azetidines via a Tandem Ring-Opening Ring-Closing Procedure

Andrea March-Cortijos
b  School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK
,
Timothy J. Snape*
a  School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK, Fax: +44(1772)892929   Email: tjsnape@uclan.ac.uk
,
Nicholas J. Turner
b  School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK
› Author Affiliations
Further Information

Publication History

Received: 16 January 2012

Accepted after revision: 23 March 2012

Publication Date:
25 May 2012 (online)


Abstract

The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.

 
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