Palladium-Catalysed Direct Arylation of Heteroaromatics Using Unprotected Iodoanilines with Inhibition of the Amination Reaction

Anissa Beladhria; Kassem Beydoun; Hamed Ben Ammar; Ridha Ben Salem; Henri Doucet

doi:10.1055/s-0031-1291124

Synthesis, Inhaltsverzeichnis

Synthesis 2012; 44(14): 2264-2276
DOI: 10.1055/s-0031-1291124

paper

Palladium-Catalysed Direct Arylation of Heteroaromatics Using Unprotected Iodoanilines with Inhibition of the Amination Reaction

Authors

Anissa Beladhria

^aLaboratoire Laboratoire de Chimie Organique Appliquée, (99 UR 12-13) Université de Gabès, Faculté des Sciences de Gabès, 6072 Gabès, Tunisia

^bInstitut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes ‘Catalyse et Organometalliques’, Campus de Beaulieu, 35042 Rennes, France, Fax: +33(2)23236939 eMail: henri.doucet@univ-rennes1.fr

^cLaboratoire de Chimie Organique Physique (99 UR 12-13) Université de Sfax, Faculté des Sciences de Sfax, Route de la Soukra km 4, 3038 Sfax, Tunisia
Kassem Beydoun

^bInstitut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes ‘Catalyse et Organometalliques’, Campus de Beaulieu, 35042 Rennes, France, Fax: +33(2)23236939 eMail: henri.doucet@univ-rennes1.fr
Hamed Ben Ammar*

^aLaboratoire Laboratoire de Chimie Organique Appliquée, (99 UR 12-13) Université de Gabès, Faculté des Sciences de Gabès, 6072 Gabès, Tunisia
Ridha Ben Salem

^cLaboratoire de Chimie Organique Physique (99 UR 12-13) Université de Sfax, Faculté des Sciences de Sfax, Route de la Soukra km 4, 3038 Sfax, Tunisia
Henri Doucet*

^bInstitut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes ‘Catalyse et Organometalliques’, Campus de Beaulieu, 35042 Rennes, France, Fax: +33(2)23236939 eMail: henri.doucet@univ-rennes1.fr

Abstract

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Abstract

The palladium-catalysed direct arylation of heteroaromatics with unprotected iodoanilines proceeds in moderate to high yields using only 1 mol% Pd(OAc)₂ as the catalyst and potassium acetate as the base. No amination reaction was observed under these conditions. A wide variety of heteroarenes have been successfully employed.

Key words

catalysis - amines - heterocycles - palladium - green chemistry

Volltext

Referenzen

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