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Int J Sports Med 2012; 33(02): 114-122
DOI: 10.1055/s-0031-1291186
Training &Testing
© Georg Thieme Verlag KG Stuttgart · New York

Exercise Training Improves Vasoreactivity in the Knee Artery

L. E. Delaney   *
1   Department of Biomedical Sciences, University of Missouri, Columbia, United States
,
A. A. Arce-Esquivel   *
1   Department of Biomedical Sciences, University of Missouri, Columbia, United States
,
K. Kuroki
4   Veterinary Pathobiology, University of Missouri, Columbia, United States
,
M. H. Laughlin
1   Department of Biomedical Sciences, University of Missouri, Columbia, United States
2   Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, United States
3   Dalton Cardiovascular Research Center, University of Missouri, Columbia, United States
› Author Affiliations
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Publication History



accepted after rivision 30 August 2011

Publication Date:
17 November 2011 (online)

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Abstract

Physical activity has been shown to enhance endothelial function of central and peripheral vascular beds. The primary purpose of the present study was to test the hypothesis that a short-term exercise training program would result in enhanced endothelium-dependent vasorelaxation of a major artery supplying blood flow to the knee joint, the middle genicular artery. Female Yucatan miniature swine were randomly assigned into exercise trained (n=7) or sedentary (n=7) groups. Exercise trained pigs underwent a daily exercise training program on treadmills for 7 days. In vitro assessment of vasorelaxation was determined in a dose response manner by administrating increasing doses of 3 different dilators; adenosine diphosphate, bradykinin, and sodium nitroprusside. The role of nitric oxide synthase and cyclooxygenase pathways in vasomotor responses was evaluated with specific inhibitors using nitro-L-arginine methyl ester and indomethacin incubation, respectively. The results of this investigation indicate that adenosine and bradykinin-induced endothelium-dependent vasorelaxation were significantly enhanced in middle genicular artery from exercise trained pigs (p<0.05). Endothelium-independent vasorelaxation was not altered with exercise training as determined by the response to sodium nitroprusside. The findings of the present investigation indicate that short-term exercise training enhances endothelial function of middle genicular artery through adaptations in the nitric oxide synthase and by non-nitric oxide synthase, non-cyclooxygenase pathways.

Key words

physical activity - vasorelaxation - knee vasculature
*

* Both authors contributed equally to the manuscript.


 

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