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Horm Metab Res 2011; 43(13): 938-943
DOI: 10.1055/s-0031-1291334
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

Perinatal Polyunstaurated Fatty Acids Supplementation Causes Alterations in Fuel Homeostasis in Adult Male Rats but does not Offer Resistance Against STZ-induced Diabetes

G. van Dijk
1   Center for Behavior and Neurosciences, Unit Neuroendocrinology, University of Groningen, Groningen, The Netherlands
,
A. Kacsándi
2   Physical Activity and Nutrition Unit, Research Institute of Sport Sciences, Semmelweis University, Budapest, Hungary
,
D. É Kóbor-Nyakas
2   Physical Activity and Nutrition Unit, Research Institute of Sport Sciences, Semmelweis University, Budapest, Hungary
,
E. Hőgyes
3   Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
,
C. Nyakas
2   Physical Activity and Nutrition Unit, Research Institute of Sport Sciences, Semmelweis University, Budapest, Hungary
4   Unit Molecular Neurobiology, University of Groningen, Groningen, The Netherlands
› Author Affiliations
Further Information

Publication History

received 20 July 2011

accepted 06 October 2011

Publication Date:
22 November 2011 (online)

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Abstract

Maternal factors can have major imprinting effects on homeostatic mechanisms in the developing fetus and newborn. Here we studied whether supplemented perinatal polyunsaturated fatty acids (PUFAs) influence energy balance and fuel homeostasis later in life. Between day 10 after conception and day 10 after delivery, female rats were subjected to chow enriched with 10% fish-oil (FO-rich). Fish oil contains high concentrations of n-3 biosynthesis endpoint products, which may have caused the increased membrane phospholipid incorporation (particularly derived from the long-chain 20 +:n-3 PUFAs) in 10-day old pup brains. Adult male offspring of FO-rich fed rats had reduced body weight (− 20%) at 3 months, and had lower levels of plasma leptin (− 54%), insulin (− 41%), triglycerides (− 65%), and lactate (− 46%) than controls. All differences between groups were lost 48 h after streptozotocin (STZ) treatment. At 4.5 months of age, body weights of FO-rich were still lower (− 6%) than controls, but were associated with increased food intake, and increased insulin sensitivity (following intraperitoneal injection) to lower blood glucose levels relative to controls. We concluded that perinatal FO supplementation has lasting effects on body weight homeostasis and fuel metabolism in male offspring, but does not offer resistance against STZ-induced diabetes.

Key words

docosahexaenoic acid - leptin - adiponectin - insulin - fetal programming
 

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