Autonomic Modulation Following Exercise is Impaired in HIV Patients

J. Borges; P. Soares; P. Farinatti

doi:10.1055/s-0031-1297954

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(04): 320-324
DOI: 10.1055/s-0031-1297954

Clinical Sciences

Autonomic Modulation Following Exercise is Impaired in HIV Patients

Authors

J. Borges

¹Oswaldo Cruz Institute, Laboratory of Cardiovascular Investigation, Rio de Janeiro, Brazil
P. Soares

²Fluminense Federal University, Department of Physiology and Pharmacology, Rio de Janeiro, Brazil
P. Farinatti

³Rio de Janeiro State University, School of Physical Education, Rio de Janeiro, Brazil

Abstract

The autonomic modulation in HIV patients undergoing highly active antiretroviral therapy (HAART) was investigated. The heart rate variability (HRV) was assessed in 13 HIV patients (43±2 years) and 10 healthy controls (31±5 years) at rest, during exercise, and recovery. All time (standard deviation of NN intervals, SDNN; root mean of squared sum of successive differences, rMSSD; relative number of pairs of adjacent RR intervals differing more than 50 ms, pNN50) and frequency (Low Frequency, LF; High Frequency, HF) HRV components were lower in HIV patients at rest [SDNN (HIV: 44.2±3.9 ms vs. Control: 65.5±9.8 ms; P=0.04); rMSSD (HIV: 27.2±3.6 ms vs. Control: 49.3±8.3 ms; P=0.02); pNN50 (HIV: 8.8±2.9% vs. Control: 26.5±7.0%; P=0.02); LF (HIV: 502.4±80.5 ms² vs. Control: 1302.8±446.4 ms²; P=0.04); HF (HIV: 296.4 ± 62.3 ms² vs. Control: 986.3±280.6 ms²; P=0.01)] and post-exercise [SDNN (HIV: 32.3±3.5 ms vs. Control: 55.8±5.9 ms; P=0.002); rMSSD (HIV: 17.4±3.1 ms vs. Control: 36.6±4.6 ms; P=0.002); pNN50 (HIV: 2.9±1.2% vs. Control: 14.7±3.4%; P=0.001); LF (HIV: 404.9±102.6 ms² vs. Control: 910.1±214.2 ms²; P=0.03); HF (HIV: 147.6 ± 40.1 ms vs. Control: 554.5±135.0 ms²; P=0.004)]. No between-group differences were found during exercise (P>0.05 for all comparisons). In conclusion, HIV patients showed impaired autonomic modulation, with reduced parasympathetic activity at rest and during post-exercise recovery.

Key words

AIDS - autonomic dysfunction - heart rate variability - autonomic nervous system

Full Text

References

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