Aktuelle Kardiologie 2012; 1(1): 30-37
DOI: 10.1055/s-0031-1298363
Übersichtsarbeit
Georg Thieme Verlag KG Stuttgart · New York

Stabile Angina pectoris: wann Revaskularisation und wann Medikament?

Stable Angina: When Revascularisation and When Medication Alone?
M. Vöhringer
1   Robert-Bosch-Krankenhaus Stuttgart
,
U. Sechtem
1   Robert-Bosch-Krankenhaus Stuttgart
› Author Affiliations
Further Information

Publication History

Publication Date:
30 March 2012 (online)

Zusammenfassung

Die beiden Standbeine der Behandlung der stabilen Angina pectoris sind einerseits die medikamentöse Therapie und andererseits die Revaskularisierung mittels perkutaner Koronarintervention (PCI) oder Bypass-Chirurgie. In den letzten Jahrzehnten wurden konservative und revaskularisierende Behandlungsoptionen wesentlich weiterentwickelt. Beide Therapieformen haben auf der Basis randomisierter Studien ihren Platz in der Behandlung der verschiedenen Stadien der koronaren Herzerkrankung. Zahlreiche Untersuchungen belegen allerdings, dass lediglich Hochrisikopatienten prognostisch von einer zusätzlichen Revaskularisierungsmaßnahme profitieren. Viele Patienten können allein durch medikamentöse Therapie erfolgreich prognostisch und auch symptomatisch behandelt werden. Spricht die Angina pectoris nicht ausreichend an, können Patienten nach einem medikamentösen Therapieversuch im Verlauf immer noch revaskularisiert werden. Dieser Artikel ist eine Standortbestimmung anhand der aktuellen Studienlage entlang eines Fallbeispiels.

Abstract

The two footholds in the therapy of stable angina pectoris are medication and revascularisation by PCI or bypass surgery. Both are supported by evidence from several randomized controlled trials. With increasing effectiveness of drug therapy in the last years it becomes evident that additional revascularisation is only beneficial for high risk patients. Many patients can be treated by drug therapy alone with favourable prognostic and symptomatic outcomes. If the angina does not respond to medication patients can still be referred to revascularisation without prognostic drawback. This article summarises the actual evidence along a clinical case.

 
  • Literatur

  • 1 [Anonymous] Prevalence of coronary heart disease–United States, 2006–2010. MMWR Morb Mortal Wkly Rep 2011; 60: 1377-1381
  • 2 Al-Mallah MH, Tleyjeh IM, Abdel-Latif AA et al. Angiotensin-converting enzyme inhibitors in coronary artery disease and preserved left ventricular systolic function: a systematic review and meta-analysis of randomized controlled trials. J Am Coll Cardiol 2006; 47: 1576-1583
  • 3 Boden WE, OʼRourke RA, Teo KK et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007; 356: 1503-1516
  • 4 Califf RM, Armstrong PW, Carver JR et al. 27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 5. Stratification of patients into high, medium and low risk subgroups for purposes of risk factor management. J Am Coll Cardiol 1996; 27: 1007-1019
  • 5 Christian TF, Miller TD, Chareonthaitawee P et al. Prevalence of normal resting left ventricular function with normal rest electrocardiograms. Am J Cardiol 1997; 79: 1295-1298
  • 6 Diamond GA. A clinically relevant classification of chest discomfort. J Am Coll Cardiol 1983; 1: 574-575
  • 7 Fox K, Garcia MA, Ardissino D et al. [Guidelines on the management of stable angina pectoris; the experts of the European Society of Cardiology on the management of stable angina pectoris]. Eur Heart J 2006; 27: 1341-1381
  • 8 Frye RL, August P, Brooks MM et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med 2009; 360: 2503-2515
  • 9 Grundy SM, Cleeman JI, Merz CN et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 2004; 44: 720-732
  • 10 Hachamovitch R, Berman DS, Shaw LJ et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 1998; 97: 535-543
  • 11 Hachamovitch R, Hayes SW, Friedman JD et al. Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation 2003; 107: 2900-2907
  • 12 Hueb W, Lopes N, Gersh BJ et al. Ten-year follow-up survival of the Medicine, Angioplasty, or Surgery Study (MASS II): a randomized controlled clinical trial of 3 therapeutic strategies for multivessel coronary artery disease. Circulation 2010; 122: 949-957
  • 13 Hueb W, Soares PR, Gersh BJ et al. The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one-year results. J Am Coll Cardiol 2004; 43: 1743-1751
  • 14 Juul-Moller S, Edvardsson N, Jahnmatz B et al. Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. Lancet 1992; 340: 1421-1425
  • 15 Mark DB, Hlatky MA, Harrell jr. FE et al. Exercise treadmill score for predicting prognosis in coronary artery disease. Ann Intern Med 1987; 106: 793-800
  • 16 Nashef SA, Roques F, Michel P et al. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg 1999; 16: 9-13
  • 17 Nilsson J, Algotsson L, Hoglund P et al. Early mortality in coronary bypass surgery: the EuroSCORE versus The Society of Thoracic Surgeons risk algorithm. Ann Thorac Surg 2004; 77: 1235-1239 discussion 1239–1240
  • 18 Pijls NH, van Schaardenburgh P, Manoharan G et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol 2007; 49: 2105-2111
  • 19 Rihal CS, Raco DL, Gersh BJ et al. Indications for coronary artery bypass surgery and percutaneous coronary intervention in chronic stable angina: review of the evidence and methodological considerations. Circulation 2003; 108: 2439-2445
  • 20 Schomig A, Mehilli J, de Waha A et al. A meta-analysis of 17 randomized trials of a percutaneous coronary intervention-based strategy in patients with stable coronary artery disease. J Am Coll Cardiol 2008; 52: 894-904
  • 21 Shaw LJ, Berman DS, Maron DJ et al. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation 2008; 117: 1283-1291
  • 22 Skinner JS, Smeeth L, Kendall JM et al. NICE guidance. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin. Heart 2010; 96: 974-978
  • 23 Swedberg K, Komajda M, Bohm M et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 2010; 376: 875-885
  • 24 Tonino PA, De Bruyne B, Pijls NH et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009; 360: 213-224
  • 25 Trikalinos TA, Alsheikh-Ali AA, Tatsioni A et al. Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis. Lancet 2009; 373: 911-918
  • 26 Velazquez EJ, Lee KL, Deja MA et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med 2011; 364: 1607-1616
  • 27 Wilson SR, Scirica BM, Braunwald E et al. Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 Trial. J Am Coll Cardiol 2009; 53: 1510-1516
  • 28 Yusuf S, Zucker D, Peduzzi P et al. Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet 1994; 344: 563-570