Facial Plast Surg 2011; 27(6): 517-522
DOI: 10.1055/s-0031-1298784
© Thieme Medical Publishers

Neuromodulators: Available Agents, Physiology, and Anatomy

Kartik Nettar1 , Corey Maas1
  • 1Aesthetic and Facial Plastic Surgery Unit, The Maas Clinic, San Francisco, California
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Publikationsverlauf

Publikationsdatum:
28. Dezember 2011 (online)

ABSTRACT

Neuromodulators have risen to the forefront of aesthetic medicine. By reversibly relaxing target muscles, neuromodulators exhibit their effect by softening hyperfunctional lines. An understanding of their physiology, relevant facial anatomy, and current agents is imperative for a successful aesthetic practice.

REFERENCES

  • 1 Simpson L L. The origin, structure, and pharmacological activity of botulinum toxin.  Pharmacol Rev. 1981;  33 155-188
  • 2 Rossetto O, Seveso M, Caccin P, Schiavo G, Montecucco C. Tetanus and botulinum neurotoxins: turning bad guys into good by research.  Toxicon. 2001;  39 27-41
  • 3 Ahn M S, Catten M, Maas C S. Temporal brow lift using botulinum toxin A.  Plast Reconstr Surg. 2000;  105 1129-1135 discussion 1136-1139
  • 4 Maas C S, Kim E J. Temporal brow lift using botulinum toxin A: an update.  Plast Reconstr Surg. 2003;  112 (5, Suppl) 109S-112S discussion 113S-114S
  • 5 Janfaza P, Cheney M L. Superficial structures of the face, head, and parotid region. In: Janfaza P, Nadol J B, Galla R J, et al, eds. Surgical Anatomy of the Head and Neck. Philadelphia: Lippincott Williams and Wilkins; 2000: 1-48
  • 6 Loos B M, Maas C S. Relevant anatomy for botulinum toxin facial rejuvenation.  Facial Plast Surg Clin North Am. 2003;  11 439-443
  • 7 Carruthers J, Fagien S, Matarasso S L. Botox Consensus Group . Consensus recommendations of the use of botulinum toxin type A in facial aesthetics.  Plast Reconstr Surg. 2004;  114 13s-19s
  • 8 Matarasso A, Matarasso S L, Brandt F S, Bellman B. Botulinum A exotoxin for the management of platysma bands.  Plast Reconstr Surg. 1999;  103 645-652 discussion 653-655
  • 9 Alam M, Dover J S, Klein A W, Arndt K A. Botulinum a exotoxin for hyperfunctional facial lines: where not to inject.  Arch Dermatol. 2002;  138 1180-1185
  • 10 Northington M E, Huang C C. Dry eyes and superficial punctate keratitis: a complication of treatment of glabelar dynamic rhytides with botulinum exotoxin A.  Dermatol Surg. 2004;  30 (12 Pt 2) 1515-1517
  • 11 Aristodemou P, Watt L, Baldwin C, Hugkulstone C. Diplopia associated with the cosmetic use of botulinum toxin a for facial rejuvenation.  Ophthal Plast Reconstr Surg. 2006;  22 134-136
  • 12 Ramirez A L, Reeck J, Maas C S. Preliminary experience with botulinum toxin type B in hyperkinetic facial lines.  Plast Reconstr Surg. 2002;  109 2154-2155
  • 13 Ramirez A L, Reeck J, Maas C S. Botulinum toxin type B (MyoBloc) in the management of hyperkinetic facial lines.  Otolaryngol Head Neck Surg. 2002;  126 459-467
  • 14 Moy R, Maas C, Monheit G, Huber M B. Reloxin Investigational Group . Long-term safety and efficacy of a new botulinum toxin type A in treating glabellar lines.  Arch Facial Plast Surg. 2009;  11 77-83
  • 15 Monheit G, Carruthers A, Brandt F, Rand R. A randomized, double-blind, placebo-controlled study of botulinum toxin type A for the treatment of glabellar lines: determination of optimal dose.  Dermatol Surg. 2007;  33 (1 Spec No.) S51-S59
  • 16 Brin M F, Blitzer A. Botulinum toxin: dangerous terminology errors.  J R Soc Med. 1993;  86 493-494
  • 17 Pickett A M, Hambleton P. Dose standardisation of botulinum toxin.  Lancet. 1994;  344 474-475
  • 18 Hambleton P, Pickett A M. Potency equivalence of botulinum toxin preparations.  J R Soc Med. 1994;  87 719
  • 19 Marion M H, Sheehy M, Sangla S, Soulayrol S. Dose standardisation of botulinum toxin.  J Neurol Neurosurg Psychiatry. 1995;  59 102-103
  • 20 Ascher B, Rzany B J, Grover R. Efficacy and safety of botulinum toxin type A in the treatment of lateral crow's feet: double-blind, placebo-controlled, dose-ranging study.  Dermatol Surg. 2009;  35 1478-1486
  • 21 Dressler D. Routine use of Xeomin in patients previously treated with Botox: long term results.  Eur J Neurol. 2009;  16 (Suppl 2) 2-5
  • 22 Jankovic J. Clinical efficacy and tolerability of Xeomin in the treatment of blepharospasm.  Eur J Neurol. 2009;  16 (Suppl 2) 14-18
  • 23 Dressler D. Comparing Botox and Xeomin for axillar hyperhidrosis.  J Neural Transm. 2010;  117 317-319
  • 24 Benecke R. Xeomin in the treatment of cervical dystonia.  Eur J Neurol. 2009;  16 (Suppl 2) 6-10
  • 25 Frevert J. Xeomin: an innovative new botulinum toxin type A.  Eur J Neurol. 2009;  16 (Suppl 2) 11-13

Kartik Nettar

Aesthetic and Facial Plastic Surgery Unit, The Maas Clinic

2400 Clay Street, San Francisco, CA 94115

eMail: Drnettar@maasclinic.com

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