Klinische Neurophysiologie 2012; 43(1): e1-e11
DOI: 10.1055/s-0031-1298958
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New York

Diagnostik und Therapieoptionen bei Dystonien

Diagnosis and Therapeutic Options in DystoniaK.  A. M.  Pauls1 , L.  Timmermann1
  • 1Klinik und Poliklinik für Neurologie, Uniklinik Köln
Further Information

Publication History

Publication Date:
05 March 2012 (online)

Lernziele

Kenntnisse über

Epidemiologie Verlauf und Gesundheitsbeeinträchtigung Genetik Diagnostik Therapieoptionen der Dystonie

Literatur

  • 1 Castelon Konkiewitz E et al. Service-based survey of dystonia in munich.  Neuroepidemiology. 2002;  21 202-206
  • 2 Risch N et al. Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population.  Nat Genet. 1995;  9 152-159
  • 3 Li S C et al. A prevalence survey of Parkinson’s disease and other movement disorders in the People’s Republic of China.  Arch Neurol. 1985;  42 655-657
  • 4 Müller J et al. The prevalence of primary dystonia in the general community.  Neurology. 2002;  59 941-943
  • 5 Defazio G et al. Epidemiology of primary dystonia.  Lancet Neurol. 2004;  3 673-678
  • 6 Fuchs T, Ozelius L J. Genetics of dystonia.  Semin Neurol. 2011;  31 441-448
  • 7 Raymond D, Bressman S B. Early-Onset Primary Dystonia (DYT1).. In: Pagon R A, Bird T D, Dolan C R, et al, eds GeneReviews.. Seattle; 1993. im Internet: http://www.ncbi.nlm.nih.gov/books/NBK1492/ Stand; 08.02.2012
  • 8 Volkmann J et al. Leitlinie der DGN – Dystonie.. In: Diener H C, Putzki N, Hrsg Leitlinien für Diagnostik und Therapie in der Neurologie.. 4. Aufl. Stuttgart: Thieme; 2008: 118-124
  • 9 Ozelius L J, Bressman S B. Genetic and clinical features of primary torsion dystonia.  Neurobiol Dis. 2011;  42 127-135
  • 10 Ceballos-Baumann A. Dystonien.. In: Ceballos-Baumann A, Conrad B, Hrsg Bewegungsstörungen.. 2. Aufl. Stuttgart: Thieme; 2005: 128-180
  • 11 Vanek Z, Jankovic J. Dystonia in corticobasal degeneration.  Mov Disord. 2001;  16 252-257
  • 12 Rafal R D, Friedman J H. Limb dystonia in progressive supranuclear palsy.  Neurology. 1987;  37 1546-1549
  • 13 Barclay C L, Lang A E. Dystonia in progressive supranuclear palsy.  J Neurol Neurosurg Psychiatry. 1997;  62 352-356
  • 14 Jankovic J. Blepharospasm and oromandibular-laryngeal-cervical dystonia: a controlled trial of botulinum A toxin therapy.  Adv Neurol. 1988;  50 583-591
  • 15 Lees A J et al. Treatment of cervical dystonia hand spasms and laryngeal dystonia with botulinum toxin.  J Neurol. 1992;  239 1-4
  • 16 Tsui J K et al. Botulinum toxin in the treatment of writer’s cramp: a double-blind study.  Neurology. 1993;  43 183-185
  • 17 Jankovic J, Schwartz K S. Longitudinal experience with botulinum toxin injections for treatment of blepharospasm and cervical dystonia.  Neurology. 1993;  43 834-836
  • 18 Brans J W et al. Botulinum toxin versus trihexyphenidyl in cervical dystonia: a prospective, randomized, double-blind controlled trial.  Neurology. 1996;  46 1066-1072
  • 19 Burke R E et al. Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl.  Neurology. 1986;  36 160-164
  • 20 Nutt J G et al. Cranial dystonia: double-blind crossover study of anticholinergics.  Neurology. 1984;  34 215-217
  • 21 Jankovic J. Treatment of hyperkinetic movement disorders with tetrabenazine: a double-blind crossover study.  Ann Neurol. 1982;  11 41-47
  • 22 Vidailhet M L et al. Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia.  N Engl J Med. 2005;  352 459-467
  • 23 Kupsch A et al. Pallidal deep-brain stimulation in primary generalized or segmental dystonia.  N Engl J Med. 2006;  355 1978-1990
  • 24 Müller J et al. Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial.  Mov Disord. 2008;  23 131-134
  • 25 Vidailhet M L et al. Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: a prospective 3 year follow-up study.  Lancet Neurol. 2007;  6 223-229
  • 26 Cif L et al. Long-term follow-up of DYT1 dystonia patients treated by deep brain stimulation: an open-label study.  Mov Disord. 2010;  25 289-299
  • 27 Gruber D et al. Long-term effects of pallidal deep brain stimulation in tardive dystonia.  Neurology. 2009;  73 53-58
  • 28 Reese R et al. Long-term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation.  Mov Disord. 2011;  26 691-698
  • 29 Gruber D et al. Pallidal and thalamic deep brain stimulation in myoclonus-dystonia.  Mov Disord. 2010;  25 1733-1743
  • 30 Azoulay-Zyss J et al. Bilateral deep brain stimulation of the pallidum for myoclonus-dystonia due to epsilon-sarcoglycan mutations: a pilot study.  Arch Neurol. 2011;  68 94-98
  • 31 Vidailhet M et al. Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study.  Lancet Neurol. 2009;  8 709-717
  • 32 Timmermann L et al. Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation.  Brain. 2010;  133 701-712
  • 33 Munchau A et al. Prospective study of selective peripheral denervation for botulinum-toxin resistant patients with cervical dystonia.  Brain. 2001;  124 769-783
  • 34 Walker R H et al. Intrathecal baclofen for dystonia: benefits and complications during six years of experience.  Mov Disord. 2000;  15 1242-1247
  • 35 Albright A L et al. Intrathecal baclofen for generalized dystonia.  Dev Med Child Neurol. 2001;  43 652-657
  • 36 Krack P, Vercueil L. Review of the functional surgical treatment of dystonia.  Eur J Neurol. 2001;  8 389-399

Univ.-Prof. Dr. Lars Timmermann

Klinik und Poliklinik für Neurologie, Uniklinik Köln

Kerpener Straße 62

50924 Köln

Email: Lars.timmermann@uk-koeln.de

    >