Informationen aus Orthodontie & Kieferorthopädie 2011; 43(04): 285-294
DOI: 10.1055/s-0031-1301065
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Behandlung von multiplen Gingivarezessionen der Klasse III: eine randomisierte klinische Studie[*]

Treatment of Class III Multiple Gingival Recessions: A Randomized-Clinical Trial
S. Aroca
1   Department of Periodontology, Faculty of Dentistry, University of Szeged, Szeged, Hungary
,
T. Keglevich
2   Department of Periodontology, Semmelweis University, Budapest, Hungary
,
D. Nikolidakis
3   Department of Periodontology and Biomaterials, Dental School, University Medical Center Nijmegen, Nijmegen, The Netherlands
,
I. Gera
2   Department of Periodontology, Semmelweis University, Budapest, Hungary
,
K. Nagy
4   Departent of Oral surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary
,
R. Azzi
5   Department of Periodontology, Paris – Denis Diderot University, UFR of Odontology, Paris, France
,
D. Etienne
6   Department of Periodontology, Service of Odontology, Pitié-Salpêtrière Hospital, AP-HP, Paris – Denis Diderot University, UFR of Odontology, Paris, France
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
30. Dezember 2011 (online)

Zusammenfassung

Hintergrund:

Ziel der vorliegenden kontrollierten randomisierten Studie im Split-Mouth-Design war es zu untersuchen, ob sich das Behandlungsergebnis bei multiplen Rezessionen der Klasse III mit einer modifizierten Tunneltechnik und einem Bindegewebstransplantat unter Verwendung von Schmelzmatrixproteinen gegenüber dem bloßen chirurgischen Verfahren verbessert.

Material und Methoden:

In die Studie wurden an einer Klinik für Parodontologie insgesamt 20 gesunde Probanden im durchschnittlichen Alter von 31,7 Jahren aufgenommen. Die Patienten hatten mindestens 3 benachbarte Gingivarezessionen auf beiden Seiten eines Kiefers. Sie wurden mithilfe einer modifizierten Tunneltechnik und einem Bindegewebstransplantat behandelt. Auf der Testseite wurde zusätzlich ein Schmelzmatrixprotein verwendet. Zu Beginn der Studie, nach 28 Tagen sowie 3, 6 und 12 Monate später wurden klinische Befunde erhoben. Die Ergebnisse werden patientenbezogen vorgelegt.

Ergebnisse:

Die durchschnittliche Wurzeldeckung betrug nach einem Jahr in der Testgruppe 82% und in der Kontrollgruppe 83%. Eine vollständige Wurzeldeckung fand sich nach einem Jahr bei insgesamt 8 (38%) der 20 Operationen (Test- und Kontrollgruppe).

Schlussfolgerungen:

Die Ergebnisse nach einem Jahr lassen darauf schließen, dass die modifizierte Tunneltechnik in Verbindung mit einem Bindegewebstransplantat zu vorhersagbaren Ergebnissen bei der Behandlung von multiplen Gingivarezessionen der Klasse III führt. Die zusätzliche Verwendung von Schmelzmatrixproteinen hatte keine Auswirkungen auf die durchschnittlichen klinischen Ergebnisse.

Abstract

Background:

The aim of this controlled randomized split-mouth study was to evaluate whether a modified tunnel/connective tissue graft (CTG) technique – enamel matrix derivative (EMD) combination will improve the treatment of multiple class III recession when compared with the same technique alone.

Materials and methods:

20 healthy subjects with a mean age of 31.7 years, were enrolled for the trial in a university periodontal clinic. Patients with at least 3 adjacent gingival recessions on both sides of the mouth were treated with a modified tunnel/CTG technique. On the test side, an EMD was used in addition. Clinical parameters were measured at baseline, 28 days, 3, 6 and 12 months after the surgery.

Results are presented at the subject level.

Results:

The mean root coverage from baseline to 1 year post-surgery was 82% for the test group and 83% for the control group. Complete root coverage was achieved at 1 year in 8 (38%) of the 20 surgeries (experimental and control group).

Conclusions:

1-year results indicate that the modified tunnel/CTG technique is predictable for the treatment of multiple class III recession-type defects. The addition of EMD does not enhance the mean clinical outcomes.

*

* Der Artikel wurde im Original veröffentlicht im J Clin Periodontol 2010; 37: 88–97. Die deutsche Veröffentlichung erfolgt mit freundlicher Genehmigung.


 
  • Literatur

  • 1 Allen AL. Use of the supraperiosteal envelope in soft tissue grafting for root coverage. I. Rationale and technique. Int J Periodontics Restorative Dent 1994; 14 (03) 216-227
  • 2 Allen AL. Use of the supraperiosteal envelope in soft tissue grafting for root coverage. II. Clin results. Int J Periodontics Restorative Dent 1994; 14 (04) 302-315
  • 3 Aroca S, Keglevich T, Barbieri B et al. Clin evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009; 80 (02) 244-252
  • 4 Azzi R, Etienne D. Recouvrement radiculaire et reconstruction papillaire par greffon conjonctif enfoui sous un lambeau vestibulaire tunnélise et tractee coronairement. J de Parodontologie et d’Implantologie Orale 1998; 17: 71-77
  • 5 Azzi R, Etienne D, Sauvan JL et al. Root coverage and papilla reconstruction in class IV recession: a case report. Int J Periodontics Restorative Dent 1999; 19 (05) 449-455
  • 6 Azzi R, Takei HH, Etienne D et al. Root coverage and papilla reconstruction using autogenous osseous and connective tissue grafts. Int J Periodontics Restorative Dent 2001; 21 (02) 141-147
  • 7 Berlucchi I, Francetti L, Del Fabbro M et al. The influence of anatomical features on the outcome of gingival recessions treated with coronally advanced flap and enamel matrix derivative: a 1-year prospective study. J Periodontol 2005; 76 (06) 899-907
  • 8 Blomlöf J, Blomlöf L, Lindskog S. Effect of different concentrations of EDTA on smear removal and collagen exposure in periodontitis-affected root surfaces. J Clin Periodontol 1997; 24 (08) 534-537
  • 9 Bouchard P, Etienne D, Ouhayoun JP et al. Subepithelial connective tissue grafts in the treatment of gingival recessions. A comparative study of 2 procedures. J Periodontol 1994; 65 (10) 929-936
  • 10 Bruno JF, Bowers GM. Histology of a human biopsy section following the placement of a subepithelial connective tissue graft. Int J Periodontics Restorative Dent 2000; 20: 225-231
  • 11 Cairo F, Pagliaro U, Nieri M. Treatment of gingival recession with coronally advanced flap procedures: a systematic review. J Clin Periodontol 2008; 35 (8 Suppl) 136-162
  • 12 Cangini F, Cornelini R, Andreana S. Simultaneous treatment of multiple, bilateral, deep buccal recession defects with bioabsorbable barrier membranes: a case report. Quintessence Int 2003; 34 (01) 15-18
  • 13 Carnio J, Camargo PM, Kenney EB et al. Histological evaluation of 4 cases of root coverage following a connective tissue graft combined with an enamel matrix derivative preparation. J Periodontol 2002; 73 (12) 1534-1543
  • 14 Carvalho PF, da Silva RC, Cury PR et al. Modified coronally advanced flap associated with a subepithelial connective tissue graft for the treatment of adjacent multiple gingival recessions. J Periodontol 2006; 77 (11) 1901-1906
  • 15 Chambrone L, Chambrone D, Pustiglioni FE et al. Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller Class I and II recession-type defects?. J Dent 2008; 36 (09) 659-671
  • 16 Chambrone L, Sukekava F, Araujo MG et al. Root coverage procedures for the treatment of localised recession-type defects. Cochrane Database Syst Rev 2009; April 15 (02) CD007161
  • 17 Chambrone LA, Chambrone L. Subepithelial connective tissue grafts in the treatment of multiple recession-type defects. J Periodontol 2006; 77 (05) 909-916
  • 18 Cheng YF, Chen JW, Lin SJ et al. Is coronally positioned flap procedure adjunct with enamel matrix derivative or root conditioning a relevant predictor for achieving root coverage? A systemic review. J Periodontal Res 2007; 42 (05) 474-485
  • 19 Clauser C, Nieri M, Franceschi D et al. Evidence-based mucogingival therapy. Part 2: Ordinary and individual patient data meta-analyses of surgical treatment of recession using complete root coverage as the outcome variable. J Periodontol 2003; 74 (05) 741-756
  • 20 Cordioli G, Mortarino C, Chierico A et al. Comparison of 2 techniques of subepithelial connective tissue graft in the treatment of gingival recessions. J Periodontol 2001; 72 (11) 1470-1476
  • 21 Cueva MA, Boltchi FE, Hallmon WW et al. A comparative study of coronally advanced flaps with and without the addition of enamel matrix derivative in the treatment of marginal tissue recession. J Periodontol 2004; 75 (07) 949-956
  • 22 Del Pizzo M, Zucchelli G, Modica F et al. Coronally advanced flap with or without enamel matrix derivative for root coverage: a 2-year study. J Clin Periodontol 2005; 32 (11) 1181-1187
  • 23 Dembowska E, Drozdzik A.. Subepithelial connective tissue graft in the treatment of multiple gingival recession. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104 (03) e1-e7
  • 24 Esposito M, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev 2003; 2 CD003875
  • 25 Esposito M, Grusovin MG, Coulthard P et al. Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev 2005; Oct 19 (04) CD003875
  • 26 Georges P, Nisand D, Etienne D et al. Efficacy of the supraperiosteal envelope technique: a preliminary comparative clinical study. Int J Periodontics Restorative Dent 2009; 29 (02) 201-211
  • 27 Guiha R, el Khodeiry S, Mota L et al. Histological evaluation of healing and revascularization of the subepithelial connective tissue graft. J Periodontol 2001; 72 (04) 470-478
  • 28 Hägewald S, Spahr A, Rompola E et al. Comparative study of Emdogain and coronally advanced flap technique in the treatment of human gingival recessions. A prospective controlled clinical study. J Clin Periodontol 2002; 29 (01) 35-41
  • 29 Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997; 24 (9 Pt 2) 658-668
  • 30 Hammarström L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 1997; 24 (9 Pt 2) 669-677
  • 31 Han JS, John V, Blanchard SB et al. Changes in gingival dimensions following connective tissue grafts for root coverage: comparison of two procedures. J Periodontol 2008; 79 (08) 1346-1354
  • 32 Henderson RD, Greenwell H, Drisko C et al. Predictable multiple site root coverage using an acellular dermal matrix allograft. J Periodontol 2001; 72 (05) 571-582
  • 33 Hürzeler MB, Weng D. A single-incision technique to harvest subepithelial connective tissue grafts from the palate. Int J Periodontics Restorative Dent 1999; 19 (03) 279-287
  • 34 Julious SA, Campbell MJ. Sample size calculations for paired or matched ordinal data. Statist Med 1998; 17 (14) 1635-1642
  • 35 Karring T, Cumming BR, Oliver RC et al. The origin of granulation tissue and its impact on postoperative results of mucogingival surgery. J Periodontol 1975; 46 (10) 577-585
  • 36 Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967; 38 (06) Suppl: 610-616
  • 37 Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963; 21: 533-551
  • 38 Mariotti A. Efficacy of chemical root surface modifiers in the treatment of periodontal disease. A systematic review. Ann Periodontol 2003; 8 (01) 205-226
  • 39 McGuire MK, Cochran DL. Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 2: Histological evaluation. J Periodontol 2003; 74(8): 1126-1135
  • 40 Miller PJ. A classification of marginal tissue recession. Int J Periodontics Restorative Dent 1985; 5 (02) 8-13
  • 41 Modica F, Del Pizzo M, Roccuzzo M et al. Coronally advanced flap for the treatment of buccal gingival recessions with and without enamel matrix derivative. A split-mouth study. J Periodontol 2000; 71 (11) 1693-1698
  • 42 Moses O, Artzi Z, Sculean A et al. Comparative study of two root coverage procedures: a 24-month follow-up multicenter study. J Periodontol 2006; 77 (02) 195-202
  • 43 Müller HP, Eger T, Schorb A. Gingival dimensions after root coverage with free connective tissue grafts. J Clin Periodontol 1998; (5): 424-430
  • 44 Murata M, Okuda K, Momose M et al. Root coverage with cultured gingival dermal substitute composed of gingival fibroblasts and matrix: a case series. Int J Periodontics Restorative Dent 2008; 28 (05) 461-467
  • 45 Nemcovsky CE, Artzi Z, Tal H et al. A multicenter comparative study of two root coverage procedures: coronally advanced flap with addition of enamel matrix proteins and subpedicle connective tissue graft. J Periodontol 2004; 75 (04) 600-607
  • 46 Nordland WP, Sandhu HS, Perio C. Microsurgical technique for augmentation of the interdental papilla: three case reports. Int J Periodontics Restorative Dent 2008; 28 (06) 543-549
  • 47 Oates TW, Robinson M, Gunsolley JC. Surgical therapies for the treatment of gingival recession. A systematic review. Ann Periodontol 2003; 8 (01) 303-320
  • 48 O’Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol 1972; 43 (01) 38
  • 49 Ouhayoun JP, Sawaf MH, Gofflaux JC et al. Re-epithelialization of a palatal connective tissue graft transplanted in a non-keratinized alveolar mucosa: a histological and biochemical study in humans. J Periodontal Research 1988; 23 (02) 127-133
  • 50 Pagliaro U, Nieri M, Rotundo R et al. Clinical guidelines of the Italian Society of Periodontology for the reconstructive surgical treatment of angular bony defects in periodontal patients. J Periodontol 2008; 79 (12) 2219-2232
  • 51 Pilloni A, Paolantonio M, Camargo PM. Root coverage with a coronally positioned flap used in combination with enamel matrix derivative: 18-month clinical evaluation. J Periodontol 2006; 77 (12) 2031-2039
  • 52 Pini Prato GP, Baldi C, Nieri M et al. Coronally advanced flap: the post-surgical position of the gingival margin is an important factor for achieving complete root coverage. J Periodontol 2005; 76 (05) 713-722
  • 53 Rasperini G, Silvestri M, Schenk RK et al. Clinical and histologic evaluation of human gingival recession treated with a subepithelial connective tissue graft and enamel matrix derivative (Emdogain): a case report. Int J Periodontics Restorative Dent 2000; 20 (03) 269-275
  • 54 Ribeiro FS, Zandim DL, Pontes AE et al. Tunnel technique with a surgical maneuver to increase the graft extension: case report with a 3-year follow-up. J Periodontol 2008; 79 (04) 753-758
  • 55 Roccuzzo M, Bunino M, Needleman I et al. Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review. J Clin Periodontol 2002; 29 (Suppl. 03) 178-194 discussion 195–196
  • 56 Sato S, Yamada K, Kato T et al. Treatment of Miller Class III recessions with enamel matrix derivative (Emdogain) in combination with subepithelial connective tissue grafting. Int J Periodontics Restorative Dent 2006; 26 (01) 71-77
  • 57 Sculean A, Donos N, Blaes A et al. Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study. J Periodontol 1999; 70 (03) 255-262
  • 58 Sculean A, Kiss A, Miliauskaite A et al. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 2008; 35 (09) 817-824
  • 59 Serino G, Wennström JL, Lindhe J et al. The prevalence and distribution of gingival recession in subjects with a high standard of oral hygiene. J Clin Periodontol 1994; 21 (01) 57-63
  • 60 Spahr A, Haegewald S, Tsoulfidou F et al. Coverage of Miller class I and II recession defects using enamel matrix proteins versus coronally advanced flap technique: a 2-year report. J Periodontol 2005; 76 (11) 1871-1880
  • 61 Tözüm TF, Dini FM. Treatment of adjacent gingival recessions with subepithelial connective tissue grafts and the modified tunnel technique. Quintessence Int 2003; 34 (01) 7-13
  • 62 Wennström JL. Mucogingival therapy. Ann Periodontol 1996; 1 (01) 671-701
  • 63 Zabalegui I, Sicilia A, Cambra J et al. Treatment of multiple adjacent gingival recessions with the tunnel subepithelial connective tissue graft: a clinical report. Int J Periodontics Restorative Dent 1999; 19 (02) 199-206
  • 64 Zucchelli G, De Sanctis M.. Treatment of multiple recession-type defects in patients with esthetic demands. J Periodontol 2000; 71 (09) 1506-1514
  • 65 Zucchelli G, De Sanctis M. Long-term outcome following treatment of multiple Miller class I and II recession defects in esthetic areas of the mouth. J Periodontol 2005; 76 (12) 2286-2292
  • 66 Zuhr O, Fickl S, Wachtel H et al. Covering of gingival recessions with a modified microsurgical tunnel technique: case report. Int J Periodontics Restorative Dent 2007; 27 (05) 457-463