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Laryngorhinootologie 2012; 91(S 01): S86-S101
DOI: 10.1055/s-0032-1306272
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© Georg Thieme Verlag KG Stuttgart · New York

Transorale Therapiestrategien bei Kopf-Hals-Tumoren

Transoral Treatment Strategies in Head and Neck Tumors
C. Arens
1   Universitäts-HNO-Klinik, Otto-von-Guericke-Universität, Magdeburg
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Publication History

Publication Date:
28 March 2012 (online)

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Zusammenfassung

Die transorale minimal-invasive Chirurgie führt zu einer erheblichen Minderung des Operationstraumas im Vergleich zu transzervikalen offenen Zugängen sowie zu einem Paradigmenwechsel in der operativen Therapie von Kopf-Hals-Tumoren. In selektierten Fällen erlaubt sie zudem, die Morbidität der Patienten ohne Verschlechterung der onkologischen Ergebnisse zu reduzieren. Dadurch erfahren die transoralen Operationstechniken eine zunehmende Akzeptanz und eine Erweiterung der Indikationsstellung. Infolgedessen entwickeln sich neue chirurgische Verfahren mit Verbesserung der dazu erforderlichen Instrumente.

Im vorliegenden Artikel werden die transoralen Therapiestrategien in Abhängigkeit von ihren anatomischen Lokalisationen und deren Indikationen beschrieben sowie Angaben aus der Literatur hinsichtlich Entwicklung und Ergebnisse diskutiert.

Abstract

Transoral Treatment Strategies in Head and Neck Tumors

The introduction of transoral endoscopic surgery resulted in a significant reduction of surgical trauma and a paradigm change from transcervical to transoral surgical treatment in head and neck tumors. In selected cases minimally invasive transoral resections allow a reduction of morbidity without deteriorating oncological results. Thus, transoral surgical techniques gained more acceptance, led to an extension of the indications and technologies as well as an improvement of surgical instruments.

Depending on the anatomical localization transoral treatment strategies and their indications are described and relevant literature is discussed according to new developments and results.

Schlüsselwörter

Transorale Chirurgie - Endoskopie - Laser - minimal-invasive Chirurgie - Karzinom

Key words

transoral surgery - endoscopy - laser - minimal-invasive surgery - cancer
 

  • Literatur

  • 1 Posner MR, Wirth LJ. Cetuximab and radiotherapy for head and neck cancer. N Engl J Med 2006; 354: 623-636
    CrossrefPubMedGoogle Scholar
  • 2 Bozzini P, Lichtleiter J. Pract Arzneykunde Wundarzneykunst
    PubMed
  • 3 Bozzini P. Der Lichtleiter oder die Beschreibung einer einfachen Vorrichtung und ihrer Anwendung zur Erleuchtung innerer Höhlen und Zwischenräume des lebenden animalischen Körpers. Verlag des Landes Industrie Comptoir, Weimar 1807
    PubMedGoogle Scholar
  • 4 Green H. Morbid Growths Within the Larynx. In: On the Surgical Treatment of Polypi of the Larynx, and Oedema of the Glottis. G.P. Putnam; New York: 1852: 46-65
    Google Scholar
  • 5 Kahler O. Die bösartigen Neubildungen des Kehlkopfs. Die endolaryngealen Operationen. In: Denker D, Kahler O. Handbuch der Hals-Nasen-Ohrenheilkunde, Bd. V. Springer; Berlin: 1929
    Google Scholar
  • 6 Kirstein A. Autoskopie des Larynx und der Trachea. Arch Laryngol Rhinol 1895; 3: 156
    PubMedGoogle Scholar
  • 7 Kirstein A. Autoskopie des Larynx und der Trachea (Besichtigung ohne Spiegel). Berl Un Wschr 1895; 22: 476-478
    PubMedGoogle Scholar
  • 8 Kirstein A. Fortschritte in der Untersuchung des Rachens und des Kehlkopfes ohne Spiegel. Allgem Med Zentralzeitung 1895; 48
    PubMedGoogle Scholar
  • 9 Killian G. Über die Schwebelaryngoskopie (Demonstration). Verb dt Laryngol 1912; 12: 747-748
    PubMedGoogle Scholar
  • 10 Seiffert A. Untersuchungsmethoden des Kehlkopfes. In: Denker D, Kahler O Handbuch Hals-Nasen-Ohrenheilkunde, Bd. I. Springer: Berlin; 1925: 843
    Google Scholar
  • 11 Lynch RC. Suspension Laryngoscopy and its accomplishments. Trans Amer Laryngol Ass 1915; 323-352
    PubMedGoogle Scholar
  • 12 Kleinsasser O. Die Laryngomikroskopie (Lupenlaryngoskopie) und ihre Bedeutung für die Erkennung der Vorerkrankungen und Frühformen des Stimmlippenkarzinoms. Arch Ohrenheilk 1962; 180: 724-727
    PubMedGoogle Scholar
  • 13 Strong MS, Jako GJ. Laser surgery in the larynx. Early clinical experience with continuous CO2-Laser. Ann Otol Rhinol Laryngol 1972; 81: 791
    Google Scholar
  • 14 Ambrosch P. Laser im oberen Aerodigestivtrakt bei bösartigen Erkrankungen. Laryngorhinootol 2003; 82 (Suppl. 01) 114-143
    PubMedGoogle Scholar
  • 15 Steiner W. Experience in endoscopic laser surgery of malignant tumors of the upper aero-digestive-tract. Adv Otorhinolaryngol 1988; 39: 135-144
    PubMedGoogle Scholar
  • 16 Grossenbacher R. Laserchirurgie in der Oto-Rhino-Laryngologie. Thieme; Stuttgart: 1985
    Google Scholar
  • 17 Rudert H. Erfahrungen mit dem CO2-Laser unter besonderer Berücksichtigung der Therapie von Stimmbandcarcinomen. Laryngorhinootol 1983; 62: 493-498
    PubMedGoogle Scholar
  • 18 Steiner W, Ambrosch P, Hess CF, Kron M. Organ preservation by transoral microsurgery in piriform sinus carcinoma. Otolaryngol Head Neck Surg 2001; 124: 58-67
    CrossrefPubMedGoogle Scholar
  • 19 Werner JA, Dünne AA, Folz BJ, Lippert BM. Transoral laser microsurgery in carcinomas of the oral cavity, pharynx and larynx. Cancer Control 2002; 9: 379-386
    PubMedGoogle Scholar
  • 20 Eckel HE, Staar S, Volling P, Sittel C, Damm M, Jungehülsing M. Surgical treatment for hypopharynx carcinoma: Feasibility, mortality, and results. Otolaryngol Head Neck Surg 124: 561-569
    PubMedGoogle Scholar
  • 21 Steiner W, Fierek O, Ambrosch P, Hommerich CP, Kron M. Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head and Neck Surg 2003; 129: 36-43
    CrossrefPubMedGoogle Scholar
  • 22 Steiner W. Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol 1993; 14: 116-121
    CrossrefPubMedGoogle Scholar
  • 23 Glanz H, Kimmich T, Eichhorn T, Kleinsasser O. Behandlungsergebnisse bei 584 Kehlkopfcarcinomen an der Hals-Nasen-Ohrenklinik der Universität Marburg. HNO 1989; 37: 1-10
    PubMedGoogle Scholar
  • 24 Nakayama M, Brandenburg JH. Clinical underestimation of laryngeal cancer. Predictive indicators. Arch Otolaryngol Head Neck Surg 1993; 119: 950-957
    CrossrefPubMedGoogle Scholar
  • 25 Eckel HE, Peretti G, Remacle M, Werner JA. Endoscopic approach. In: Surgery of Larynx and Trachea. Remacle M, Eckel HE. (eds.) 2010: 197-214
    CrossrefGoogle Scholar
  • 26 Arens C, Just T, Betz CS, Kraft M. Fortschritte der endoskopischen Diagnostik bei Dysplasien und Karzinomen des Larynx. HNO 2011; im Druck
    PubMedGoogle Scholar
  • 27 Kraft M, Bruns N, Hugens-Penzel M, Arens C. Clinical Value of Endosonography in the Assessment of Laryngeal Cancer. Head Neck 2011; im Druck
    PubMedGoogle Scholar
  • 28 Panosetti E, Luboinski B, Mamelle G, Richard JM. Multiple synchronous and metachronous cancers of the upper aerodigestive tract: a nine -year study. Laryngoscope 1989; 99: 1267-1273
    PubMedGoogle Scholar
  • 29 Silver CE, Beitler JJ, Shah AR, Rinaldo A, Ferlito A. Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol 2009; 266: 1333-1352
    CrossrefPubMedGoogle Scholar
  • 30 Hartl DM, Ferlito A, Brasnu DF, Langendijk JA, Rinaldo A, Silver CE, Wolf GT. Evidence-based review of treatment options for patients with glottic cancer. Head Neck 2011; Im Druck
    PubMedGoogle Scholar
  • 31 Iro H, Mantsopoulos K, Zenk J, Waldfahrer F, Psychogios G. Ergebnisse der transoralen Laserresektion bei T1-2 Karzinomen von Oropharynx, Hypopharynx und Larynx. Laryngorhinootol 2011; 90: 481-485
    PubMedGoogle Scholar
  • 32 Rödel RM, Steiner W, Müller RM, Kron M, Matthias C. Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck 2009; 31: 583-592
    CrossrefPubMedGoogle Scholar
  • 33 Motta G, Esposito E, Motta S, Tartaro G, Testa D. CO2 laser surgery in the treatment of glottic cancer. Head Neck 2005; 27: 566-573
    CrossrefPubMedGoogle Scholar
  • 34 Peretti G, Piazza C, Cocco D, De Benedetto L, Del Bon F, Redaelli De Zinis LO, Nicolai P. Transoral CO2 laser treatment for Tis-T3 glottic cancer: the University of Brescia experience on 595 patients. Head Neck 2010; 32: 977-983
    PubMedGoogle Scholar
  • 35 Eckel HE, Thumfart W, Jungehülsing M, Sittel C, Stennert E. Transoral laser surgery for early glottic carcinoma. Eur Arch Otorhinolaryngol 2000; 257: 221-226
    CrossrefPubMedGoogle Scholar
  • 36 Kleinsasser O, Glanz H, Kimmich T. Endoscopic surgery of vocal cord cancers. HNO 1988; 36: 412-416
    PubMedGoogle Scholar
  • 37 Steiner W, Vogt P, Ambrosch P, Kron M. Transoral carbon dioxide laser microsurgery for recurrent glottic carcinoma after radiotherapy. Head Neck 2004; 26: 477-484
    CrossrefPubMedGoogle Scholar
  • 38 Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg 2007; 15: 82-88
    CrossrefPubMedGoogle Scholar
  • 39 Barthel SW, Esclamado RM. Primary radiation therapy for early glottis cancer. Otolaryngol Head Neck Surg 2001; 124: 35-39
    CrossrefPubMedGoogle Scholar
  • 40 Colden D, Zeitels SM, Hillman RE, Jarboe J, Bunting G, Spanou K. Stroboscopic assessment of vocal fold keratosis and glottic cancer. Ann Otol Rhinol Laryngol 2001; 110: 293-298
    PubMedGoogle Scholar
  • 41 Haas E, Bildstein P. Die Bedeutung der Stroboskopie für die Früherkennung des Stimmlippenkrebses. Laryngol-Rhinol-Otol 1974; 53: 169-172
    PubMedGoogle Scholar
  • 42 Piazza C, DBon F, Peretti G, Nicolai P. Biologic endoscopy: optimization of upper aerodigestive tract cancer evaluation. Curr Opin Otolaryngol Head Neck Surg 2011; 19: 67-76
    CrossrefPubMedGoogle Scholar
  • 43 Zeitels SM, Hillman RE, Franco RA, Bunting GW. Voice and treatment outcome from phonosurgical management of early glottic cancer. Ann Otol Rhinol Laryngol Suppl 2002; 190: 3-20
    PubMedGoogle Scholar
  • 44 Karatzanis AD, Psychogios G, Zenk J, Waldfahrer F, Hornung J, Velegrakis GA, Iro H. Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope 2009; 119: 1704-1708
    CrossrefPubMedGoogle Scholar
  • 45 Arens C. Open partial resection for malignant glottic tumors. In: Surgery of Larynx and Trachea. Remacle M, Eckel HE. (eds.). 2010: 215-220
    Google Scholar
  • 46 Bolzoni Villaret A, Piazza C, Redaelli De Zinis LO, Cattaneo A, Cocco D, Peretti G. Phonosurgery after endoscopic cordectomies. I. Primary intracordal autologous fat injection after transmuscular resection: preliminary results. Eur Arch Otorhinolaryngol 2007; 264: 1179-1184
    CrossrefPubMedGoogle Scholar
  • 47 Karatzanis AD, Waldfahrer F, Psychogios G, Hornung J, Velegrakis GA, Iro H. Effect of repeated laser microsurgical operations on laryngeal cancer prognosis. Head Neck 2010; 32: 921-928
    PubMedGoogle Scholar
  • 48 Eckel HE. Local recurrences following transoral laser surgery for early glottis carcinoma: frequency, management, and outcome. Ann Otol Rhinol Laryngol 2001; 110: 7-15
    PubMedGoogle Scholar
  • 49 Bradley PJ, Rinaldo A, Suárez C, Shaha AR, Leemans CR, Langendijk JA, Patel SG, Ferlito A. Primary treatment of the anterior vocal commissure squamous carcinoma. Eur Arch Otorhinolaryngol 2006; 263: 879-888
    CrossrefPubMedGoogle Scholar
  • 50 Hartl DM, Landry G, Hans S, Marandas P, Brasnu DF. Organ preservation surgery for laryngeal squamous cell carcinoma: low incidence of thyroid cartilage invasion. Laryngoscope 2010; 120: 1173-1176
    PubMedGoogle Scholar
  • 51 Peretti G, Piazza C, Mensi MC, Magnoni L, Bolzoni A. Endoscopic treatment of cT2 glottic carcinoma: prognostic impact of different pT subcategories. Ann Otol Rhinol Laryngol 2005; 114: 579-586
    PubMedGoogle Scholar
  • 52 Karatzanis AD, Psychogios G, Zenk J, Waldfahrer F, Hornung J, Velegrakis GA, Iro H. Evaluation of available surgical management options for early supraglottic cancer. Head Neck 2010; 32: 1048-1055
    PubMedGoogle Scholar
  • 53 Ambrosch P, Kron M, Steiner W. Carbon dioxide laser microsurgery for early supraglottic carcinoma. Ann Otol Rhinol Laryngol 1998; 107: 680-688
    CrossrefPubMedGoogle Scholar
  • 54 Eckel HE. Endoscopic laser resection of supraglottic carcinoma. Otolaryngol Head Neck Surg 1997; 117: 681-687
    CrossrefPubMedGoogle Scholar
  • 55 Rudert HH, Werner JA, Höft S. Transoral carbon dioxide laser resection of supraglottic carcinoma. Ann Otol Rhinol Laryngol 1999; 108: 819-827
    PubMedGoogle Scholar
  • 56 Csanády M, Czigner J, Vass G, Jóri J. Transoral CO2 laser management for selected supraglottic tumors and neck dissection. Eur Arch Otorhinolaryngol 2011; 268: 1181-1186
    CrossrefPubMedGoogle Scholar
  • 57 Rodrigo JP, Cabanillas R, Franco V, Suarez C. Efficacy of routine bilateral neck dissection in the management of the N0 neck in T1-T2 unilateral supraglottic cancer. Head Neck 2006; 28: 534-539
    CrossrefPubMedGoogle Scholar
  • 58 Rodrigo JP, Suarez C, Silver CE, Rinaldo A, Ambrosch P, Fagan JJ, Genden EM, Ferlito A. Transoral laser surgery for supraglottic cancer. Head Neck 2008; 30: 658-666
    CrossrefPubMedGoogle Scholar
  • 59 Vilaseca I, Bernal-Sprekelsen M, Luis Blanch J. Transoral laser microsurgery for T3 laryngeal tumors: prognostic factors. Head Neck 2009; 32: 929-938
    PubMedGoogle Scholar
  • 60 Hinni ML, Salassa JR, Grant DG, Pearson BW, Hayden RE, Martin A, Christiansen H, Haughey BH, Nussenbaum B, Steiner W. Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg 2007; 133: 1198-1204
    CrossrefPubMedGoogle Scholar
  • 61 Steiner W, Herbst M. Combined therapy of hypopharyngeal carcinoma consisting of endoscopic laser surgery and postoperative radiotherapy. In: Sauer R, Schwab W. (eds.). Combined therapy of oropharyngeal and hypopharyngeal carcinoma. Urban & Schwarzenberg; München, Wien, Baltimore: 1987: 108-113
    Google Scholar
  • 62 Hoffmann HT, Karnell LH, Funk GF, Robinson RA, Menck HR. The National Cancer Data Base report on cancer of the head and neck. Arch Otolaryngol Head Neck Surg 1998; 124: 951-962
    PubMedGoogle Scholar
  • 63 Glanz H. Pathomorphologische Aspekte zur transoralen Resektion des Hypopharynxkarzinoms mit Kehlkopferhalt. Laryng-Rhino-Otol 1999; 78: 654-662
    PubMedGoogle Scholar
  • 64 Hall SF, Groome PA, Irish J, O’Sullivan B. The natural history of patients with squamous cell carcinoma of the hypopharynx. Laryngoscope 2008; 118: 1362-1371
    CrossrefPubMedGoogle Scholar
  • 65 Cooper JS, Porter K, Mallin K. National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck 2009; 31: 748-758
    CrossrefPubMedGoogle Scholar
  • 66 Pingree TF, Davis RK, Reichman O, Derrick L. Treatment of hypopharyngeal carcinoma: a 10-year review of 1 362 cases. Laryngoscope 1987; 97: 901-904
    PubMedGoogle Scholar
  • 67 Kraus DH, Zelefsky MJ, Brock HA, Huo J, Harrison LB, Shah JP. Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx. Otolaryngol Head Neck Surg 1997; 116: 637-641
    CrossrefPubMedGoogle Scholar
  • 68 Dietz A, Keilholz U, Flentje M. Organerhalt bei Larynx- und Hypopharynx-Karzinomen. Was ist das? Onkologe 2007; 13: 118-128
    PubMedGoogle Scholar
  • 69 Eckel HE, Staar S, Volling P, Sittel C, Damm M, Jungehülsing M. Surgical treatment for hypopharynx carcinoma: feasibility, mortality, and results. Otolaryngol Head Neck Surg 2001; 124: 561-569
    CrossrefPubMedGoogle Scholar
  • 70 Sewnaik A, Hoorweg JJ, Knegt PP, Wieringa MH, van der Beek JM, Kerrebijn JD. Treatment of hypopharyngeal carcinoma: analysis of nationwide study in the Netherlands over a 10-year period. Clin Otolaryngol 2005; 30: 52-57
    CrossrefPubMedGoogle Scholar
  • 71 Gupta T, Chopra S, Agarwal JP, Laskar SG, D’cruz AK, Shrivastava SK, Dinshaw KA. Squamous cell carcinoma of the hypopharynx: single-institution outcome analysis of a large cohort of patients treated with primary non-surgical approaches. Acta Oncol 2009; 48: 541-548
    CrossrefPubMedGoogle Scholar
  • 72 Takes RP, Strojan P, Silver CE, Bradley PJ, Haigentz Jr M, Wolf GT, Shaha AR, Hartl DM, Olofsson J, Langendijk JA, Rinaldo A, Ferlito A. Current trends in initial management of hypopharyngeal cancer: the declining use of open surgery. Head Neck 2010; Nov 10. Im Druck
    PubMedGoogle Scholar
  • 73 Steiner W, Ambrosch P, Hess CF, Kron M. Organ preservation by transoral laser microsurgery in piriform sinus carcinoma. Otolaryngol Head Neck Surg 2001; 124: 58-67
    CrossrefPubMedGoogle Scholar
  • 74 Nakamura K, Shioyama Y, Saski T, Ohga S, Saku M, Urashima Y, Yoshitake T, Nakashima T, Kuratomi Y, Komune S, Terashima H, Honda H. Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx. Int J Radiat Oncol Biol Phys 2005; 62: 680-683
    CrossrefPubMedGoogle Scholar
  • 75 Bernal-Sprekelsen M, Dazert S, Sudhoff H, Blanch JL, Vilaseca I. Komplikationen in der transoralen Laserchirurgie maligner Tumoren des Larynx und Hypopharynx Laryngorhinootologie. 2009; 88: 28-34
    PubMedGoogle Scholar
  • 76 Karatzanis AD, Psychogios G, Waldfahrer F, Zenk J, Hornung J, Velegrakis GA, Iro H. T1 und T2 hypopharyngeal cancer treatment with laser microsurgery. J Surg Oncol 2010; 102: 27-33
    CrossrefPubMedGoogle Scholar
  • 77 Mori K, Chijiwa K, Umeno H, Umeno T, Sakamoto K. Laser debulking surgery prior to radiotherapy for T1-T2 carcinoma of the hypopharynx. Nihon Jibiinkoka Gakkai Kaiho 2000; 103: 977-985
    CrossrefPubMedGoogle Scholar
  • 78 Martin A, Jäckel MC, Christiansen H, Mahmoodzada M, Kron M, Steiner W. Organ preserving transoral laser microsurgery for cancer of the hypopharynx. Laryngoscope 2008; 118: 398-402
    CrossrefPubMedGoogle Scholar
  • 79 Rudert HH, Höft S. Transoral carbon-dioxide laser resection of hypopharyngeal carcinoma. Eur Arch Otorhinolaryngol 2003; 260: 198-206
    PubMedGoogle Scholar
  • 80 Huang ZG, Ni X, Fang JG, Chen XH, Yu ZK, Chen XJ, Zhou WG, Huang JW, Han DM. Transoral carbon dioxide laser surgery for treatment of hypopharyngeal carcinoma. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009; 44: 722-725
    PubMedGoogle Scholar
  • 81 Eckel HE, Staar S, Volling P, Sittel C, Damm M, Jungehuelsing M. Surgical treatment for hypopharynx carcinoma: feasibility, mortality, and results. Otolaryngol Head Neck Surg 2001; 124: 561-569
    CrossrefPubMedGoogle Scholar
  • 82 Grant DG, Salassa JR, Hinni ML, Pearson BW, Hayden RE, Perry WC. Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer. Otolaryngol Head Neck Surg 2008; 138: 606-613
    CrossrefPubMedGoogle Scholar
  • 83 Grant DG, Hinni ML, Salassa JR, Perry WC, Hayden RE, Casler JD. Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg 2009; 135: 1225-1230
    CrossrefPubMedGoogle Scholar
  • 84 Rich JT, Milov S, Lewis Jr JS, Thorstad WL, Adkins DR, Haughey BH. Transoral laser microsurgery (TLM) adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope 2009; 119: 1709-1719
    CrossrefPubMedGoogle Scholar
  • 85 Christiansen H, Hermann RM, Martin A, Florez R, Kahler E, Nitsche M, Hille A, Steiner W, Hess CF, Pradier O. Long-term follow-up after transoral laser microsurgery and adjuvant radiotherapy for advanced recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2006; 65: 1067-1074
    CrossrefPubMedGoogle Scholar
  • 86 Pradier O, Christiansen H, Schmidberger H, Martin A, Jäckel MC, Steiner W, Ambrosch P, Kahler E, Hess CF. Adjuvant radiotherapy after transoral laser microsurgery for advanced squamous carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2005; 63: 1368-1377
    CrossrefPubMedGoogle Scholar
  • 87 Moncrieff M, Sandilla J, Clark J, Clifford A, Shannon K, Gao K, O’Brien C. Outcomes of primary surgical treatment of T1 and T2 carcinomas of the oropharynx. Laryngoscope 2009; 119: 307-311
    CrossrefPubMedGoogle Scholar
  • 88 Röösli C, Tschudi DC, Studer G, Braun J, Stoeckli SJ. Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx. Laryngoscope 2009; 119: 534-540
    CrossrefPubMedGoogle Scholar
  • 89 Walvekar RR, Li RJ, Gooding WE, Gibson MK, Heron D, Johnson JT, Ferris RL. Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx. Laryngoscope 2008; 118: 2129-2134
    CrossrefPubMedGoogle Scholar
  • 90 Cosmidis A, Rame JP, Dassonville O. T1-T2 N0 oropharyngeal cancers treated with surgery alone. A GETTEC study. Eur Arch Otorhinolaryngol 2004; 261: 276-281
    CrossrefPubMedGoogle Scholar
  • 91 Galati LT, Myers EN, Johnson JT. Primary surgery for early SCC of the tonsil. Head Neck 2000; 22: 294-296
    CrossrefPubMedGoogle Scholar
  • 92 Hicks Jr WL, Kuriakose MA, Loree TR, Orner JB, Schwartz G, Mullins A, Donaldson C, Winston JM, Bakamjian VY. Surgery versus radiation therapy as single-modality treatment of tonsillar fossa carcinoma: the Roswell Park Cancer Institute experience (1971-1991). Laryngoscope 1998; 108: 1014-1019
    CrossrefPubMedGoogle Scholar
  • 93 Eckel HE, Volling P, Pototschnig C, Zorowka P, Thumfart W. Transoral laser resection with staged discontinuous neck dissection for oral cavity and oropharynx squamous cell carcinoma. Laryngoscope 1995; 105: 53-60
    CrossrefPubMedGoogle Scholar
  • 94 Tschudi D, Stoeckli S, Schmid S. Quality of life after different treatment modalities for carcinoma of the oropharynx. Laryngoscope 2003; 113: 1949-1954
    PubMedGoogle Scholar
  • 95 Parsons JT, Mendenhall WM, Stringer SP, Amdur RJ, Hinerman RW, Villaret DB, Moore-Higgs GJ, Greene BD, Speer TW, Cassisi NJ, Million RR. Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 2002; 94: 2967-2980
    CrossrefPubMedGoogle Scholar
  • 96 Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010; 363: 24-35
    CrossrefPubMedGoogle Scholar
  • 97 Klussmann JP, Preuss SF, Speel EJ. Humane Papillomviren und Oropharynxkarzinome. Molekulare Interaktion und klinische Auswirkung. HNO 2009; 57: 113-122
    CrossrefPubMedGoogle Scholar
  • 98 Lace MJ, Anson JR, Klussmann JP, Wang DH, Smith EM, Haugen TH, Turek LP. Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers. J Virol 2011; 85: 1645-1654
    CrossrefPubMedGoogle Scholar
  • 99 Desai SC, Sung CK, Jang DW, Genden EM. Transoral robotic surgery using a carbon dioxide flexible laser for tumors of the upper aerodigestive tract. Laryngoscope 2008; 118: 2187-2189
    CrossrefPubMedGoogle Scholar
  • 100 Barbash GI, Glied SA. New technology and health care costs – the case of robot-assisted surgery. N Engl J Med 2010; 363: 701-704
    CrossrefPubMedGoogle Scholar
  • 101 Weinstein GS, O’Malley Jr BW, Desai SC, Quon H. Transoral robotic surgery: does the ends justify the means?. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 126-131
    CrossrefPubMedGoogle Scholar
  • 102 Weinstein GS, Quon H, O’Malley Jr BW, Kim GG, Cohen MA. Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgical trial. Laryngoscope 2010; 120: 1749-1755
    CrossrefPubMedGoogle Scholar
  • 103 Cohen MA, Weinstein GS, O’Malley Jr BW, Feldman M, Quon H. Transoral robotic surgery and human papillomavirus status: oncologic results. Head Neck 2011; 33: 573-580
    CrossrefPubMedGoogle Scholar
  • 104 Boudreaux BA, Rosenthal EL, Magnuson JS, Newman JR, Desmond RA, Clemons L, Carroll WR. Robot-assisted surgery for upper aerodigestive track neoplasms. Arch Otolaryngol Head Neck Surg 2009; 135: 397-401
    CrossrefPubMedGoogle Scholar
  • 105 Dean NR, Rosenthal EL, Carroll WR, Kostrzewa JP, Jones VL, Desmond RA, Clemons L, Magnuson JS. Robotic-assisted surgery for primary or recurrent oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 2010; 136: 380-384
    CrossrefPubMedGoogle Scholar
  • 106 Moore EJ, Olsen KD, Kasperbauer JL. Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes. Laryngoscope 2009; 119: 2156-2164
    CrossrefPubMedGoogle Scholar
  • 107 Iseli TA, Kulbersh BD, Iseli CE, Carroll WR, Rosenthal EL, Magnusson JS. Functional outcomes after transoral robotic surgery for head and neck cancer. Otolaryngol Head Neck Surg 2009; 141: 166-171
    CrossrefPubMedGoogle Scholar
  • 108 Gourin CG, Johnson JT. A contemporary review of indications for primary surgical care of patients with squamous cell carcinoma of the head and neck. Laryngoscope 2009; 119: 2124-2134
    CrossrefPubMedGoogle Scholar
  • 109 Udoff RA, Elam JC, Gourin CG. Primary surgery for oropharyngeal cancer. Otolaryngol Head Neck Surg 2010; 143: 644-649
    CrossrefPubMedGoogle Scholar
  • 110 Duvvuri U, Simental Jr AA, D’Angelo G, Johnson JT, Ferris RL, Gooding W, Myers EN. Elective neck dissection and survival in patients with squamous cell carcinoma of the oral cavity and oropharynx. Laryngoscope 2004; 114: 2228-2234
    CrossrefPubMedGoogle Scholar
  • 111 Moore EJ, Henstrom DK, Olsen KD, Kasperbauer JL, McGree ME. Transoral resection of tonsillar squamous cell carcinoma. Laryngoscope 2009; 119: 508-515
    CrossrefPubMedGoogle Scholar
  • 112 Hartl DM, Ferlito A, Silver CE, Takes PT, Stoeckli SJ, Suárez C, Rodrigo JP, Sesterhenn AM, Snyderman CH, Terris DJ, Genden EM, Rinaldo A. Minimally invasive techniques for head and neck malignancies: current indications, outcomes and future directions. Eur Arch Otorhinolaryngol 2011; 268: 1249-1257
    CrossrefPubMedGoogle Scholar
  • 113 Cohen MA, Weinstein GS, O’Malley Jr BW, Feldman M, Quon H. Transoral robotic surgery and human papillomavirus status: Oncologic results. Head Neck 2011; 33: 573-580
    CrossrefPubMedGoogle Scholar
  • 114 Weinstein GS, O’Malley Jr BW, Snyder W, Hockstein NG. Transoral robotic surgery: supraglottic partial laryngectomy. Ann Otol Rhinol Laryngol 2007; 116: 19-23
    CrossrefPubMedGoogle Scholar
  • 115 Solares CA, Strome M. Transoral robot-assisted CO2 laser supraglottic laryngectomy: experimental and clinical data. Laryngoscope 2007; 117: 817-820
    CrossrefPubMedGoogle Scholar
  • 116 Park YM, Kim WS, Byeon HK, De Virgilio A, Jung JS, Kim SH. Feasibility of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. Oral Oncol 2010; 46: 597-602
    CrossrefPubMedGoogle Scholar
  • 117 Genden EM, Kotz T, Tong CC, Smith C, Sikora AG, Teng MS, Packer SH, Lawson WL, Kao J. Transoral robotic resection and reconstruction for head and neck cancer. Laryngoscope 2011; 121: 1668-1674
    CrossrefPubMedGoogle Scholar
  • 118 Litynski GS. Endoscopic surgery. The history of the pioneers. World J Surg 1999; 23: 745-753
    CrossrefPubMedGoogle Scholar
  • 119 Hatzinger M, Badawi JK, Häcker A. Georg Kelling (1866–1945). Der Erfinder der modernen Laparoskopie. Urologe 2006; 45: 868-871
    CrossrefPubMedGoogle Scholar
  • 120 Yeung GHC. Endoscopic thyroid surgery today: a diversity of surgical strategies. Thyroid 2002; 12: 703-706
    CrossrefPubMedGoogle Scholar
  • 121 Choe JH, Kim SW, Chung KW, Park KS, Han W, Noh DY, Oh SK, Youn YK. Endoscopic thyroidectomy using a new bilateral axillo-breast approach. World J Surg 2007; 31: 601-606
    CrossrefPubMedGoogle Scholar
  • 122 Lee KE, Kim HY, Park WS, Choe JH, Kwon MR, Oh SK, Youn YK. Postauricular and axillary approach endoscopic neck surgery: a new technique. World J Surg 2009; 33: 767-772
    CrossrefPubMedGoogle Scholar
  • 123 Schardey HM, Barone M, Pörtl S, von Ahnen M, von Ahnen T, Schopf S. Invisible scar endoscopic dorsal approach thyroidectomy: a clinical feasibility study. World J Surg 2010; 34: 2997-3006
    CrossrefPubMedGoogle Scholar
  • 124 Cougard P, Osmak-Tizon L, Balestra L, Dancea R, Goudet P. Thyroïdectomie endoscopique par une approche médiane avec insuZation gazeuse: analyse des 100 premiers patients. J Chir (Paris) 2007; 144: 297-300
    CrossrefPubMedGoogle Scholar
  • 125 Benhidjeb T, Harlaar J, Kerver A, Kleinrensink GJ, Wilhelm T. Transorale endoskopische Thyreoidektomie. Chirurg 2010; 81: 134-138
    CrossrefPubMedGoogle Scholar
  • 126 Benhidjeb T, Wilhelm T, Harlaar J, Kerver A, Kleinrensink GJ, Schneider TAJ, Stark M. Natural orifice surgery on thyroid gland: totally transoral video assisted thyroidectomy (TOVAT): report of first experimental results of a new surgical method. Surg Endosc 2009; 23: 1119-1120
    CrossrefPubMedGoogle Scholar
  • 127 Chung YS, Choe JH, Kang KH, Kim SW, Chung KW, Park KS, Han W, Noh DY, Oh SK, Youn YK. Endoscopic thyroidectomy for thyroid malignancies: comparison with conventional open thyroidectomy. World J Surg 2007; 31: 2302-2308
    CrossrefPubMedGoogle Scholar
  • 128 Benhidjeb T, Rückert JC, Burghardt J, Müller JM. Minimally invasive and endoscopic thyroid surgery. Otorinolaringologia 2009; 59: 89-95
    PubMedGoogle Scholar
  • 129 Tan CTK, Cheah WK, Delbridge L. Scarless (in the Neck). Endoscopic Thyroidectomy. An evidence-based review of published techniques. World J Surg 2008; 32: 1349-1357
    CrossrefPubMedGoogle Scholar
  • 130 Wilhelm T, Krüger J. Ultrasound studies on the shift of cervical tissues in different head and neck positions – impact on transoral endoscopic, minimally invasive and conventional thyroid surgery. Ultrasound Med Biol 2011; 37: 1430-1435
    CrossrefPubMedGoogle Scholar
  • 131 Witzel K, von Rahden BH, Kaminski C, Stein HJ. Transoral access for endoscopic thyroid resection. Surg Endosc 2008; 22: 1871-1875
    CrossrefPubMedGoogle Scholar
  • 132 Wilhelm T, Klemm W, Leschber G, Harlaar JJ, Kerver ALA, Kleinrensink GJ, Nemat A. Development of a new trans-oral endoscopic approach for mediastinal surgery based on ‘natural orifice surgery’: preclinical studies on surgical technique, feasibility, and safety. Eur J Cardiothorac Surg 2011; 39: 1001-1008
    CrossrefPubMedGoogle Scholar
  • 133 Varghese BT, Sebastian P, Abraham EK, Mathews A. Pleomorphic adenoma of minor salivary gland in the parapharyngeal space. World J Surg Oncol 2003; 25: 2
    PubMedGoogle Scholar
  • 134 Gehrking E, Gellißen J, Wollenberg B. Chirurgie der parapharyngealen Adenome. HNO 2007; 55: 135-146
    CrossrefPubMedGoogle Scholar
  • 135 Fluur E. Parapharyngeal tumors. Arch Otolaryngol 1964; 80: 557-565
    CrossrefPubMedGoogle Scholar
  • 136 John DG, Carlin WV, Brown MJ. Tumors of the parapharyngeal space. J R Coll Surg Edinb 1988; 33: 56-60
    PubMedGoogle Scholar
  • 137 Myatt HM, Remedios D. A transpalatal approach to the parapharyngeal space. J Laryngol Otol 1997; 111: 159-162
    CrossrefPubMedGoogle Scholar
  • 138 Som PM, Biller HF, Lawson W. Tumors of the parapharyngeal space: preoperative evaluation, diagnosis and surgical approaches. Ann Otol Rhinol Laryngol Suppl 1981; 90: 3-15
    PubMedGoogle Scholar
  • 139 Windfuhr JP, Sesterhenn K. Diagnostik und Zugangswege bei Tumoren des Parapharyngealraumes – Eine Übersicht. Laryngol Rhinol Otol 2002; 81: 797-806
    Article in Thieme ConnectPubMedGoogle Scholar
  • 140 Goodwin Jr WJ, Chandler JR. Transoral excision of lateral parapharyngeal space tumors presenting intraorally. Laryngoscope 1988; 98: 266-269
    PubMedGoogle Scholar
  • 141 Allison RS, Van der Waal I, Snow GB. Parapharyngeal tumours: a review of 23 cases. Clin Otolaryngol Allied Sci 1989; 14: 199-203
    PubMedGoogle Scholar
  • 142 Scholtz AW, Appenroth E, KamenJolly K, Scholtz LU, Thumfart WF. Juvenile nasopharyngeal angiofibroma: management and therapy. Laryngoscope 2001; 111: 681-687
    CrossrefPubMedGoogle Scholar
  • 143 Mistry RC, Qureshi SS, Gupta S, Gupta S. Juvenile nasopharyngeal angiofibroma: a single institution study. Indian J Cancer 2005; 42: 35-39
    CrossrefPubMedGoogle Scholar
  • 144 Granato L. Angiofibroma Juvenil - Vias de Abordagem, Técnicas e Complicações. In: Brandão LG, Ferraz AR. Cirurgia de Cabeça e Pescoço. São Paulo: Editora Roca; 1989. 2. 397-414
    Google Scholar
  • 145 Shepherd G, Pryor MD, Eric J, Moore MD, Jan L, Kasperbauer M. Endoscopic versus Traditional Approaches for Excision of Juvenile Nasopharyngeal Angiofibroma. Laryngoscope 2005; 115: 1201-1207
    CrossrefPubMedGoogle Scholar
  • 146 Thumfart WF, Platzer W, Gunkel AR, Maurer H, Brenner E. Operative Zugangswege in der HNO-Heilkunde. Thieme Verlag, Stuttgart, New York 1998; 136-153
    PubMedGoogle Scholar
  • 147 Casson PR, Bonanno PC, Converse JM. The midface degloving procedure. Plast Reconstr Surg 1974; 53: 102-103
    CrossrefPubMedGoogle Scholar
  • 148 Berghaus A. Midfacial degloving. HNO 1990; 38: 7-11
    PubMedGoogle Scholar
  • 149 Allen GA, Siegel GJ. The sublabial approach for extensive nasal and sinus resection. Laryngoscope 1981; 91: 1635-1639
    PubMedGoogle Scholar
  • 150 Dolgin SR, Zaveri VD, Casiano RR, Maniglia AJ. Different options for treatmant of inverting papilloma of the nose and paranasal sinuses: a report of 41 cases. Laryngoscope 1992; 102: 231-236
    PubMedGoogle Scholar
  • 151 Allen GA, Siegel GJ. The sublabial approach for extensive nasal and sinus resection. Laryngoscope 1981; 91: 1635-1639
    PubMedGoogle Scholar
  • 152 Draf AW, Berghaus A. Tumoren und Pseudotumoren der frontalen Schädelbasis, ausgehend von der Nase, Nasennebenhöhlen und dem Nasenrachenraum. Eur Arch Oto-Rhino-Laryngol (Suppl.I) 1993; 106-178
    PubMedGoogle Scholar
  • 153 Lund V. Surgical management of midfacial tumors: transfacial degloving, midfacial degloving, or endoscopic approach. Otolaryngol Head Neck Surg 2001; 9: 95-99
    PubMedGoogle Scholar
  • 154 Maniglia AJ, Phillips DA. Midfacial degloving for the management of nasal, sinus, and skull-base neoplasms. Otolaryngol Clin North Am 1995; 28: 1127-1143
    PubMedGoogle Scholar
  • 155 Sachs ME, Conley J, Rabuzzi DD, Blaugrund S, Price J. Degloving approach for total excision of inverted papilloma. Laryngoscope 1984; 94: 1595-1598
    PubMedGoogle Scholar
  • 156 Maniglia AJ. Indications and technique of midfacial degloving. A 15-year experience. Arch Otolaryngol Head Neck Surg 1986; 112: 750-752
    CrossrefPubMedGoogle Scholar
  • 157 Price JC, Holliday MJ, Johns ME, Kennedy DW, Richtsmeier WJ, Mattox DE. The versatile midface degloving approach. Laryngoscope 1988; 98: 291-295
    PubMedGoogle Scholar
  • 158 Price JC. Facial degloving. Rhinology chapt. 37, Wiley & Sons; New York: 1987: 1098-1123
    Google Scholar
  • 159 Götze GV. Folgezustände nach Operationen mit der “Midfacial degloving”-Technik. Dissertation. Elektronisches Dokument. ULB Sachsen-Anhalt. 2005; urn:nbn:de:gbv:3-000008437
    PubMedGoogle Scholar
  • 160 Barnes L, Eveson JW, Reichart P, Sidransky D. (eds.). World Health Organisation Classification of Tumors. Pathology and Genetics of Head and Neck Tumours. IARC Press; Lyon: 2005
  • 161 Meier JD, Oliver DA, Varvares MA. Surgical margin determination in head and neck oncology: current clinical practice. The results of an International American Head and Neck Society member survey. Head and Neck 2005; 27: 952-958
    CrossrefPubMedGoogle Scholar
  • 162 Lawson G, Matar N, Remacle M, Jamart J, Bachy V. Transoral robotic surgery for the management of head and neck tumors: learning curve. Eur Arch Otorhinolaryngol 2011; im Druck
    PubMedGoogle Scholar
  • 163 Wilhelm T, Klemm W, Nemat A. Erste klinische Anwendung der transoral endoskopischen Mediastinalchirurgie. GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery 2011; Vol: 7 DOC02 (20110414)
    PubMedGoogle Scholar