New Serratene Triterpenoids from Palhinhaea cernua and Their Cytotoxic Activity

Jian Yan; Zhong-Yu Zhou; Mei Zhang; Jing Wang; Hao-Fu Dai; Jian-Wen Tan

doi:10.1055/s-0032-1314999

Planta Medica, Table of Contents

Planta Med 2012; 78(12): 1387-1391
DOI: 10.1055/s-0032-1314999

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

New Serratene Triterpenoids from Palhinhaea cernua and Their Cytotoxic Activity

Authors

Jian Yan

¹Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Zhong-Yu Zhou

¹Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
Mei Zhang

¹Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China

³Graduate School of the Chinese Academy of Sciences, Beijing, China
Jing Wang

¹Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China

³Graduate School of the Chinese Academy of Sciences, Beijing, China
Hao-Fu Dai

²State Key Laboratory of Tropical Crops Biotechnology, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, China
Jian-Wen Tan

¹Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China

Abstract

Four new serratene triterpenoids, 3β,21β,24-trihydroxyserrat-14-en-24-(4′-hydroxybenzoate) (1), 3β,21α,24-trihydroxyserrat-14-en-3-(4′-hydroxybenzoate) (2), 3β,14α,15α,21α-tetrahydroxyserrat-14-en-3-(3′-methoxyl-4′-hydroxybenzoate) (3), and 3β,14α,15α,21α-tetrahydroxyserrat-14-en-21-acetyl-3-(4′-hydroxybenzoate) (4), together with two known ones, 5 and 6, were isolated from whole plants of Palhinhaea cernua. The structures of these new compounds were elucidated by spectroscopic methods. All the six compounds were tested for their in vitro cytotoxicity against three human cancer cell lines (K562, SMMC-7721, and SGC7901). Compound 5 showed cytotoxicity against the three test cell lines with IC₅₀ values of 20.3, 34.0, and 22.5 ug/mL, respectively. Compound 1 showed slight cytotoxicity against K562 cell lines with IC₅₀ value of 56.1 ug/mL, while no obvious inhibitory effects were detected for other compounds.

Key words

Palhinhaea cernua - Lycopodiaceae - serratene - triterpenoid - cytotoxic activity

Full Text

References

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