GNAS A-1121G Variant is Associated with Improved Diastolic Dysfunction in Response to Exercise Training in Heart Failure Patients

A. J. Alves; E. Goldhammer; F. Ribeiro; N. Eynon; S. Ben-Zaken Cohen; J. A. Duarte; J. L. Viana; M. Sagiv; J. Oliveira

doi:10.1055/s-0032-1316365

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2013; 34(03): 274-280
DOI: 10.1055/s-0032-1316365

Genetics & Molecular Biology

GNAS A-1121G Variant is Associated with Improved Diastolic Dysfunction in Response to Exercise Training in Heart Failure Patients

A. J. Alves

¹Faculty of Sport, Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal

,

E. Goldhammer

²Bnai-Zion Haifa Medical Center, Heart Institute, Haifa, Israel

,

F. Ribeiro

¹Faculty of Sport, Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal

⁶CESPU, Polytechnic Health Institute of the North, Physiotherapy Department Gandra PRD

,

N. Eynon

³Institute of Sports Exercise and Active Living, Victoria University, Melbourne, Australia

,

S. Ben-Zaken Cohen

⁴Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sport Sciences at the Wingate Institute, Netanya, United States

,

J. A. Duarte

¹Faculty of Sport, Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal

,

J. L. Viana

⁵School of Sport, Exercise and Health Sciences Loughborough, Loughborough University, United Kingdom

⁷Research Center in Sports, Health Sciences and Human Development (CIDESD), Portugal

,

M. Sagiv

⁴Genetics and Molecular Biology Laboratory, The Zinman College of Physical Education and Sport Sciences at the Wingate Institute, Netanya, United States

,

J. Oliveira

¹Faculty of Sport, Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal

› Author Affiliations

Abstract

β1-adrenergic receptors (ADRB1) and Gαs proteins (GNAS) play important roles in the regulation of cardiac function. The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 61 heart failure patients completed a 6-month exercise-training programme. Left ventricular ejection fraction (LVEF), mitral inflow velocities (deceleration time, and E/A ratio) and exercise tolerance (METs) were assessed at baseline and following exercise training. There were no associations between the studied variants and LVEF or E/A ratio measured at baseline and after exercise training. Deceleration time of early mitral flow was higher at baseline in GNAS -1211G allele carriers compared with -1211A allele homozygotes (P<0.05). Exercise training attenuated deceleration time in -1211G allele carriers (P<0.05) but not in -1211A allele homozygotes. Moreover, ADRB1 389Gly homozygotes had a greater training-induced increase in exercise tolerance than 389Arg homozygotes (P=0.04). This study shows that the functional GNAS -1121 G/A polymorphism is associated with diastolic function at baseline and in response to exercise training in heart failure patients. Furthermore, our data suggest that ADRB1 Arg389Gly polymorphism may influence exercise tolerance.

Key words

exercise - polymorphism - heart failure

Full Text

References

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