NbCl5-Promoted Synthesis of 4-Aryl-3,4-dihydrocoumarins by Multicomponent Reaction

Willian Henrique dos Santos; Luiz Carlos da Silva-Filho

doi:10.1055/s-0032-1317340

Synthesis, Table of Contents

Synthesis 2012; 44(21): 3361-3365
DOI: 10.1055/s-0032-1317340

paper

NbCl₅-Promoted Synthesis of 4-Aryl-3,4-dihydrocoumarins by Multicomponent Reaction

Willian Henrique dos Santos

Department of Chemistry, São Paulo State University (UNESP), 17033-360, Bauru, São Paulo, Brazil Fax: +55(14)31036099 Email: lcsilva@fc.unesp.br

,

Luiz Carlos da Silva-Filho*

Department of Chemistry, São Paulo State University (UNESP), 17033-360, Bauru, São Paulo, Brazil Fax: +55(14)31036099 Email: lcsilva@fc.unesp.br

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Abstract

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Abstract

Substituted 4-aryl-3,4-dihydrocoumarins are synthesized from multicomponent reactions between phenols, dimethyl malonate, and aryl aldehydes catalyzed by niobium pentachloride. This new method is simple, cost-effective, and high-yielding, and can be conducted in acceptable reaction times.

Key words

niobium pentachloride - multicomponent reaction - coumarin derivatives - Lewis acid - phenols

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References

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