Synlett 2013; 24(5): 531-534
DOI: 10.1055/s-0032-1318075
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© Georg Thieme Verlag Stuttgart · New York

Iron-Catalyzed Hydromagnesiation of Olefins

Mark D. Greenhalgh
School of Chemistry, Joseph Black Building, West Mains Road, Edinburgh, Scotland, EH9 3JJ, UK   Fax: +44(0)1316506453   Email: stephen.thomas@ed.ac.uk
,
Stephen P. Thomas*
School of Chemistry, Joseph Black Building, West Mains Road, Edinburgh, Scotland, EH9 3JJ, UK   Fax: +44(0)1316506453   Email: stephen.thomas@ed.ac.uk
› Author Affiliations
Further Information

Publication History

Received: 07 December 2012

Accepted after revision: 19 December 2012

Publication Date:
15 January 2013 (online)

Abstract

In 2012, three complementary iron-catalyzed methodologies for the hydromagnesiation of olefins have been developed. In each case, hydromagnesiation gives an alkyl, benzylic, or vinyl ­Grignard reagent that can be reacted with a variety of electrophiles to give functionalized products in good to excellent yields. The ­regio-, chemo-, and stereoselectivities of the reactions are evaluated.

 
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