Biosynthetic pathways enable the formation of diverse and sometimes highly complex
molecular architectures and, it is needless to say that they provide an inexhaustible
source of inspiration to chemists. We will present recent works from our team in the
field of biomimetic total synthesis of natural substances. We will particularly emphasize
on examples where polycyclic molecules may, in principle, be assembled through cascade
reactions from simple reactive precursors. Selected targets (mainly involving l -lysine and l -tryptophane metabolisms) that will be presented during the talk are shown in the
following figure.
Selected review articles:
- E. Gravel, E. Poupon, Nat. Prod. Rep . 2010 , 27 , 32–56.
- E. Poupon, E. Gravel. Eur. J. Org. Chem.
2008 , 27–42.
