Biomimetic oxidative derivatization of ursolic acid by using 'Ru'-porphyrin for cytotoxic activity against tumor cell lines

K Mazumder; K Tanaka; ERO Siwu; S Nozaki; Y Watanabe; K Fukase

doi:10.1055/s-0032-1325179

Planta Medica, Table of Contents

Biomimetic oxidative derivatization of ursolic acid by using 'Ru'-porphyrin for cytotoxic activity against tumor cell lines

K Mazumder ¹^,², K Tanaka ², ERO Siwu ², S Nozaki ³, Y Watanabe ³, K Fukase ²

¹Department of Pharmay, University of Science and Technology Chittagong, Foy's Lake, Pahartali, 4202, Chittagong, Bangladesh
²Department of Chemistry, Graduate School of Science, OsakaUniversity, 1–1Machikaneyama- cho, Toyonaka-shi, Osaka 560–0043, Japan
³RIKEN Center for Molecular Imaging Science, 6–7-3 Minatojima-minamimachi, Chuo-ku, Kobe-shi, Hyogo650–0047, Japan

Abstract

Ursene-type pentacyclic triterpenes, including the ursolic acid 1 and a new ursene-type pentacyclic triterpene, 7,24-dihydroxyursolic acid were isolated from medicinal plant, Saurauja roxburghii. They were tested for the cytotoxicity against C6 rat glioma and A431 human skin carcinoma cell lines.. Biomimetic chemical oxidation using the “Ru”-porphyrin derivatives a-g, six ursolic acid derivatives 2-7 were isolated, their distributions and selectivity were apparently affected by the auxiliaries, a-g.

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