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Neuropediatrics 2012; 43(06): 353-356
DOI: 10.1055/s-0032-1327771
Short Communication
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Treatment of Refractory Neonatal Seizures with Topiramate

Rudimar Riesgo
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Maria Isabel Winckler
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Lygia Ohlweiler
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Josiane Ranzan
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Michele Becker
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Socrates Salvador
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Luiza Magalhaes
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Ricardo Ribeiro
1   Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
› Author Affiliations
Further Information

Publication History

24 February 2012

17 August 2012

Publication Date:
24 September 2012 (online)

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Abstract

Objective The objective of this study is to describe the usefulness of topiramate in refractory neonatal seizures.

Results We reported the clinical off-label use of topiramate in three cases of refractory neonatal seizures of unclear origin with no response to conventional antiepileptic drugs. In all cases, the seizures were completely controlled with adding topiramate. All patients became seizure free during hospitalization and were followed by approximately 1 year after hospital discharge, with monotherapy with topiramate.

Comments The clinical off-label use of topiramate in neonatal seizures is still incipient. When searching publications in this matter, only one report was identified. Because of its efficacy for both seizures and neuroprotection, topiramate could be a useful choice in refractory neonatal seizures.

Keywords

neonatal - seizures - topiramate
 

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