New Alkaloids and Cytotoxic Principles from Sinomenium acutum

Jing-Jy Cheng; Tung-Hu Tsai; Lie-Chwen Lin

doi:10.1055/s-0032-1327785

Planta Medica, Table of Contents

Planta Med 2012; 78(17): 1873-1877
DOI: 10.1055/s-0032-1327785

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

New Alkaloids and Cytotoxic Principles from Sinomenium acutum

Authors

Jing-Jy Cheng

¹National Research Institute of Chinese Medicine, Taipei, Taiwan

⁴Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan
Tung-Hu Tsai

²Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan
Lie-Chwen Lin

¹National Research Institute of Chinese Medicine, Taipei, Taiwan

³Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan

Abstract

Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.

Key words

Sinomenium acutum - Menispermaceae - 2-demethyl-oxypalmatine - 5-ethoxycarbonylsinoracutine - cytotoxicity - angiogenesis

Full Text

References

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