Planta Med 2013; 79(01): 70-77
DOI: 10.1055/s-0032-1327927
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Ilexpublesnins C–M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens

Yuan Zhou
1   State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
,
Xing-Yun Chai
2   Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
,
Ke-Wu Zeng
1   State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
,
Jia-Yu Zhang
1   State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
,
Ning Li
1   State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
,
Yong Jiang
1   State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
,
Peng-Fei Tu
1   State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
2   Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
› Author Affiliations
Further Information

Publication History

received 20 April 2012
revised 02 September 2012

accepted 11 October 2012

Publication Date:
16 November 2012 (online)

Abstract

Eleven new triterpene saponins, ilexpublesnins C–M (111), along with ten known analogues were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 1, 2, 10, and 11 contain a 24-aldehyde, which is rare for triterpene saponins from Ilex. These compounds were evaluated in vitro for their cytotoxic effects on human cancer cell lines HepG2, HLE, BEL7402, BEL7403, BEL7405, MCF-7, and HeLa. Among them, only compounds 6 and 19 showed cytotoxicity against the MCF-7 cell line [inhibition (%): 33.14 and 34.03, respectively].

Supporting Information

 
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