Planta Med 2013; 79(05): 338-347
DOI: 10.1055/s-0032-1328287
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Sesquineolignans and Terpene-Sesquineolignans: Anti-Acetylcholinesterase Constituents from Illicium simonsii

Chuanfu Dong*
1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2  Graduate University of Chinese Academy of Sciences, Beijing, P. R. China
,
Lei Liu*
1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2  Graduate University of Chinese Academy of Sciences, Beijing, P. R. China
,
Xiaonian Li
1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Zhengye Guan
1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2  Graduate University of Chinese Academy of Sciences, Beijing, P. R. China
,
Huairong Luo
1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Yifen Wang
1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› Author Affiliations
Further Information

Publication History

received 14 December 2012
revised 21 January 2013

accepted 30 January 2013

Publication Date:
06 March 2013 (eFirst)

Abstract

Chemical investigation of the aerial parts of Illicium simonsii resulted in the isolation of nine new compounds, simonsols A−E (15), simonsins A−B (78), terpene-sesquineolignans, clovanedunnianol (9), and p-menthadunnianol (10). Compound 5 was equilibrated with 7 as an inseparable mixture. The structures were elucidated by extensive NMR and MS analysis. Compounds 9, 10, and the mixture of 5 and 7 moderately inhibited acetylcholinesterase with IC50 values of 4.58 µM, 6.55 µM, and 10.34 µM, respectively.

* The first two authors contributed equally to this work.


Supporting Information