Abstract
This study examined the effects of curcumin on the pharmacokinetic and
pharmacodynamic properties of warfarin and clopidogrel in Wistar rats.
Results showed that oral administration of curcumin at 25 mg/kg, 50 mg/kg,
and 100 mg/kg for 7 days had no substantial effects on the pharmacodynamics
of warfarin and clopidogrel in this animal model. However, oral
administration of 100 mg/kg curcumin for 7 days significantly increased the
AUC0-∞ and Cmax of the two drugs (by × 1.6 and
× 1.5, respectively, for warfarin, and × 1.61 and × 1.81, respectively, for
clopidogrel carboxylic acid). However, compared to warfarin alone, different
doses of curcumin combined with warfarin had no effects on the prothrombin
time in rats. Similarly, a combination of curcumin and clopidogrel had no
significant effect on the maximum platelet aggregation rate of rats compared
with the use of clopidogrel alone. This work demonstrated that
preadministration of 100 mg/kg curcumin affected the pharmacokinetics of
warfarin and clopidogrel but had no effect on pharmacodynamic parameters
such as anticoagulation rate and antiplatelet aggregation.
Key words
curcumin - warfarin - clopidogrel - herb-drug interaction - pharmacokinetics - pharmacodynamics
