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Planta Med 2013; 79(11): 987-994
DOI: 10.1055/s-0032-1328657
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Triterpene Saponins from Clematis mandshurica and Their Antiproliferative Activity

Yi-xia Gong
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Hui-ming Hua
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Yong-nan Xu
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
3   School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China
,
Jian-yu Liu
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
3   School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China
,
Zong-gui Yu
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Jing Ma
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Hui Zhang
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
3   School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China
,
Yong-kui Jing
4   Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
› Author Affiliations
Further Information

Publication History

received 08 November 2012
revised 20 April 2013

accepted 12 May 2013

Publication Date:
26 June 2013 (online)

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Abstract

Six new triterpene saponins, clematomandshurica saponins F–K (1–6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5–7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI50 values of 1.29, 1.50, and 0.71 µM, respectively.

Key words

Clematis mandshurica - Ranunculaceae - triterpene saponins - antiproliferative activity - prostate cancer PC-3

Supporting Information

 

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