Obesity: A Transgenerational Problem Linked to Nutrition during Pregnancy

Antonio E. Frias; Kevin L. Grove

doi:10.1055/s-0032-1328875

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2012; 30(06): 472-478
DOI: 10.1055/s-0032-1328875

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Obesity: A Transgenerational Problem Linked to Nutrition during Pregnancy

Autor*innen

Antonio E. Frias

¹Department of Obstetrics and Gynecology, Oregon Health and Science University (OHSU) Portland, Oregon

²Division of Developmental and Reproductive Sciences, Oregon National Primate Center
Kevin L. Grove

²Division of Developmental and Reproductive Sciences, Oregon National Primate Center

³Division of Neurosciences, Oregon National Primate Center, OHSU, Beaverton, Oregon

Abstract

The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.

Keywords

obesity - pregnancy - high fat diet - placenta - programming

Volltext

Referenzen

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