Management of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia

S. Vijfhuize; T. Schaible; U. Kraemer; T. E. Cohen-Overbeek; D. Tibboel; I. Reiss

doi:10.1055/s-0032-1329531

European Journal of Pediatric Surgery, Table of Contents

Eur J Pediatr Surg 2012; 22(05): 374-383
DOI: 10.1055/s-0032-1329531

Review

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Management of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia

Authors

S. Vijfhuize

¹Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
T. Schaible

²Department of Intensive Care, Kinderklinikum Mannheim, Mannheim, Germany
U. Kraemer

¹Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
T. E. Cohen-Overbeek

³Division of Prenatal Medicine, Department of Obstetrics and Gynaecology, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
D. Tibboel

¹Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
I. Reiss

¹Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands

Abstract

Pulmonary hypertension associated with congenital diaphragmatic hernia is still one of the major challenges in neonatal intensive care units. Several relevant pathways in its pathogenesis have been described and studied, but the absence of well-designed randomized controlled trials and the scattered data on the pharmacokinetics and pharmacodynamics of most of the drugs used in these patients hamper progress significantly. This review aims to give an overview of current management strategies in the antenatal and neonatal phase, and provides founded clinical recommendations.

Keywords

congenital diaphragmatic hernia - pulmonary hypertension - neonates - NO pathway

Full Text

References

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