Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

Abstract

An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 10⁸ red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.

Keywords

azathioprine - pancytopenia - 6-thioguanine nucleotides

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