Fetal Surgery in Zurich: Key Features of Our First Open in utero Repair of Myelomeningocele

Martin Meuli; Ueli Moehrlen; Alan Flake; Nicole Ochsenbein; Margaret Huesler; Peter Biro; Ianina Scheer; Sasha Tharakan; Peter Dürig; Roland Zimmermann

doi:10.1055/s-0032-1329700

European Journal of Pediatric Surgery, Inhaltsverzeichnis

Eur J Pediatr Surg 2013; 23(06): 494-498
DOI: 10.1055/s-0032-1329700

Case Gallery

Georg Thieme Verlag KG Stuttgart · New York

Fetal Surgery in Zurich: Key Features of Our First Open in utero Repair of Myelomeningocele

Martin Meuli

¹Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland

,

Ueli Moehrlen

¹Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland

,

Alan Flake

²The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

,

Nicole Ochsenbein

³Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

,

Margaret Huesler

³Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

,

Peter Biro

⁴Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland

,

Ianina Scheer

⁵Department of Radiology, University Children's Hospital Zurich, Zurich, Switzerland

,

Sasha Tharakan

¹Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland

,

Peter Dürig

⁶Effinger Center for Obstetrics and Gynecology, Zurich, Switzerland

,

Roland Zimmermann

³Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

References
1 Cameron AH. The spinal cord lesion in spina bifida cystica. Lancet 1956; 271 (6935) 171-174
2 Harrison MR, Filly RA, Golbus MS , et al. Fetal treatment 1982. N Engl J Med 1982; 307 (26) 1651-1652
3 Hutchins GM, Meuli M, Meuli-Simmen C, Jordan MA, Heffez DS, Blakemore KJ. Acquired spinal cord injury in human fetuses with myelomeningocele. Pediatr Pathol Lab Med 1996; 16 (5) 701-712
4 Meuli M, Meuli-Simmen C, Hutchins GM , et al. In utero surgery rescues neurological function at birth in sheep with spina bifida. Nat Med 1995; 1 (4) 342-347
5 Stiefel D, Copp AJ, Meuli M. Fetal spina bifida in a mouse model: loss of neural function in utero. J Neurosurg 2007; 106 (3, Suppl): 213-221
6 Adzick NS, Sutton LN, Crombleholme TM, Flake AW. Successful fetal surgery for spina bifida. Lancet 1998; 352 (9141) 1675-1676
7 Meuli M, Meuli-Simmen C, Yingling CD , et al. Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep. J Pediatr Surg 1995; 30 (7) 1028-1032 , discussion 1032–1033
8 Meuli M, Meuli-Simmen C, Yingling CD , et al. In utero repair of experimental myelomeningocele saves neurological function at birth. J Pediatr Surg 1996; 31 (3) 397-402
9 Meuli M, Meuli-Simmen C, Hutchins GM, Seller MJ, Harrison MR, Adzick NS. The spinal cord lesion in human fetuses with myelomeningocele: implications for fetal surgery. J Pediatr Surg 1997; 32 (3) 448-452
10 Bruner JP, Tulipan N, Paschall RL , et al. Fetal surgery for myelomeningocele and the incidence of shunt-dependent hydrocephalus. JAMA 1999; 282 (19) 1819-1825
11 Adzick NS, Thom EA, Spong CY , et al; MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 2011; 364 (11) 993-1004
12 Bouchard S, Davey MG, Rintoul NE, Walsh DS, Rorke LB, Adzick NS. Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. J Pediatr Surg 2003; 38 (3) 451-458 , discussion 451–458
13 Sutton LN, Adzick NS, Bilaniuk LT, Johnson MP, Crombleholme TM, Flake AW. Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele. JAMA 1999; 282 (19) 1826-1831
14 Tulipan N, Hernanz-Schulman M, Bruner JP. Reduced hindbrain herniation after intrauterine myelomeningocele repair: A report of four cases. Pediatr Neurosurg 1998; 29 (5) 274-278
15 Tulipan N, Hernanz-Schulman M, Lowe LH, Bruner JP. Intrauterine myelomeningocele repair reverses preexisting hindbrain herniation. Pediatr Neurosurg 1999; 31 (3) 137-142
16 Jellinger G. Anatomopathology of non-tumoral aqueductal stenosis. J Neurosurg Sci 1986; 30 (1–2) 1-16
17 Gloor JM, Muchant DG, Norling LL. Prenatal maternal indomethacin use resulting in prolonged neonatal renal insufficiency. J Perinatol 1993; 13 (6) 425-427
18 van der Heijden BJ, Carlus C, Narcy F, Bavoux F, Delezoide AL, Gubler MC. Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. Am J Obstet Gynecol 1994; 171 (3) 617-623