Facial plast Surg 2012; 28(06): 554-562
DOI: 10.1055/s-0032-1329930
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Pathogenesis of Infantile Hemangioma

Thuy L. Phung1, Marcelo Hochman2
  • 1Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas
  • 2The Hemangioma International Treatment Center, Charleston, South Carolina
Further Information

Publication History

Publication Date:
27 November 2012 (online)

Abstract

Cutaneous vascular anomalies are congenital disorders of abnormal vascular development and growth. Infantile hemangioma is a common type of vascular anomalies characterized by the abnormal growth of blood vessels in the early proliferative phase, followed by the gradual spontaneous regression of the lesion in the involuting phase. Over the past decade, significant advances have been made in our understanding of the cellular and molecular mechanisms that control the development, growth, and regression of infantile hemangioma. In this article, we present a comprehensive review of the current knowledge of the pathogenesis of hemangioma as well as promising research horizons and implications for new therapeutic advances.