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Z Gastroenterol 2013; 51(11): 1235-1239
DOI: 10.1055/s-0033-1335450
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Celiac Disease Screening among Healthy Blood Donors in Hungary

Zöliakie-Screening bei gesunden Blutspendern in Ungarn
M. Sárdy
1   Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
2   Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
,
Z. Kornseé
1   Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
,
D. Kelemen
1   Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
,
S. Papp
1   Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
,
M. Medvecz
1   Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
,
S. Kárpáti
1   Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
› Author Affiliations
Further Information

Publication History

18 January 2013

10 April 2013

Publication Date:
15 November 2013 (online)

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Abstract

Background: Celiac disease (CD) is a common chronic systemic autoimmune disease in Europe. The prevalence of CD in Hungarian children is estimated at 1.2 – 1.4 %. To date, however, no data on adult CD prevalence has been published.

Aims: Analysis of the serological evidence for CD among Hungarian adults in order to estimate its prevalence.

Methods: Plasma samples from 4155 healthy blood donors were anonymously screened for circulating IgA autoantibodies by a highly sensitive tissue transglutaminase ELISA. Positive results were subsequently confirmed by endomysial antibody test.

Results: Endomysial antibody test confirmed positivity in 25 samples suggesting a prevalence of CD of at least 0.6 % (1:166). Since no identification on the samples was provided, no further examinations could be done on endomysial antibody positive individuals.

Conclusions: The first serological screening study among healthy Hungarian adult blood donors showed a prevalence of CD similar to other central European countries and lower than that in Hungarian children. Among countries worldwide, the Hungarian prevalence of CD appears to be in the mid-range, although pediatric data suggest a higher prevalence.

Zusammenfassung

Hintergrund: Die Zöliakie ist eine häufige, chronische systemische Autoimmunerkrankung in Europa. Ihre Prävalenz bei Kindern in der Allgemeinbevölkerung Ungarns liegt bei 1,2 – 1,4 %. Bislang gibt es keine Daten hinsichtlich der Prävalenz bei Erwachsenen in Ungarn.

Ziele: Analyse der Seren von Erwachsenen in Ungarn zur Ermittlung der Prävalenz der Zöliakie.

Methoden: Plasmaproben von 4155 gesund erscheinenden Blutspendern wurden anonymisiert und hinsichtlich zirkulierender IgA-Autoantikörper gegen Gewebstransglutaminase mittels eines hoch sensitiven ELISA untersucht. Die positiven Ergebnisse wurden mithilfe eines Endomysium-Antikörpertests verifiziert.

Ergebnisse: Der Endomysium-Antikörpertest war bei 25 Proben positiv, insofern scheint die Prävalenz der Zöliakie bei mindestens etwa 0,6 % (1:166) zu liegen. Da die Proben anonymisiert getestet wurden, konnten die Betroffenen nicht weiter untersucht werden.

Schlussfolgerungen: Die erste serologische Screeningstudie bei gesund erscheinenden ungarischen Blutspendern lieferte eine Zöliakieprävalenz, die den Prävalenzwerten aus anderen zentraleuropäischen Ländern bei Erwachsenen gleicht, aber geringer ist als bei Kindern in Ungarn. Global gesehen liegt die Prävalenz der Zöliakie in Ungarn im mittleren Bereich, obwohl die pädiatrischen Daten eine höhere Prävalenz aufzeigen.

Schlüsselwörter

Gewebstransglutaminase - Endomysiumantikörper - Prävalenz - Zöliakie - Sprue

Key words

tissue transglutaminase - endomysial antibodies - prevalence - celiac disease - sprue
 

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