Larvicidal activity of Thipohenes from Echinops transiliensis against Aedes aegypti: Structure Activity Relationship

H Nakano; A Ali; JU Rehman; CL Cantrell; IA Khan

doi:10.1055/s-0033-1336463

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml

Share / Bookmark

Facebook X Linkedin Weibo

Planta Med 2013; 79 - P21
DOI: 10.1055/s-0033-1336463

Larvicidal activity of Thipohenes from Echinops transiliensis against Aedes aegypti: Structure Activity Relationship

H Nakano ¹, A Ali ², JU Rehman ², CL Cantrell ⁴, IA Khan ²

¹NARO Institute of Crop Science, Japan
²National Center for Natural Products Research
³Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677 USA
⁴United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University, MS 38677, USA

Congress Abstract

Compounds were isolated from Echinops transiliensis root extract and evaluated for their larvicidal activity against Aedes aegypti. Compounds belonging to thiophenes group showed larvicidal activity. Compound 1 with LD₅₀values of 0.16 ppm was the most toxic followed by Compounds 3, 5, 8, 9, 2, 4, 6 and 7. Larvicidal activity was found to be related to an increase in thiophenes rings and acetoxy groups. Among bithiophenes (3, 5, and 8), the activity increased with increase in number of acetoxy groups. Monothiophenes (2, 4, 6, 7, and 9) didn't display this increasing trend in activity.