NMR Spectroscopic Data Comparison of Diastereomeric Alkaloids from Mitragyna speciosa
Mitragyna speciosa (Korth) belongs to the Rubiaceae family and its leaves have been used traditionally as a substitute for opium. Indole alkaloids, the most common constituents, are considered the active constituents of M. speciosa [1,2]. Several indole alkaloids including mitragynine, a marker alkaloid of M. speciosa, were isolated from its leaves. The 1 H and 13C NMR spectroscopic data of various possible diastereoisomers were assigned and compared through 2D NMR techniques. Acknowledgements: The research work was supported by The United States Food and Drug Administration (FDA) Specific Cooperative Research Agreement Number 5U01FD004246. The authors are thankful to Dr. Bharathi Avula for mass analysis. References:  Takayama H, Aimi N, Sakai S. (2000) Yakugaku Zasshi, 120: 959 – 968.  Leon F, Habib E, et al. (2009) Nat Prod Commun, 4: 907 – 910.