Pharmacological Screening of Medicinal Plants for Anticancer, Antiinflammatory and Antidiabetic Activities
We report a detailed pharmacological screening of 11 medicinal plants (36 samples) growing in the Tabuk region of Saudi Arabia for cytotoxicity against HeLa S3 cells, anti-inflammatory activity (Raw cells) and adipogenesis. Three plant samples were found to be cytotoxic against HeLa S3 cells namely Commiphora africana (16.9%), Raetam ratam whole plant (8.2%), Raetam ratam roots (3.8%). Six plant samples were found active as anti-infammatory namely Artemisa seberi (28 – 0%), Commiphora africana (6 – 3%), Raetam ratam (20 – 6%), Citrullus colocynthsis whole plant (33.7%), Citrullus colocynthsis seed (40 – 1%), Ocimum bacillum (45.4%). Three plant samples were found with inhibitory adipogenesis effects namely Citrullus colocynthsis, Raetam ratam and Fagonia indica. We have also isolated several biomolecules that are responsible for all three activities mentioned above, which will be presented.