A palladium-catalyzed tandem elimination and annulation reaction has been developed.
In this way, a variety of 3-trifluoromethybenzofurans were prepared in moderate to
good yields via tandem reaction of β-chloro-β-(trifluoromethyl)styrenes with 2-iodophenols
and 2-bromophenols.
Key words
tandem reaction - trifluoromethyl - benzofuran - X-phos - palladium acetate - cesium
carbonate