Asymmetric Hydrogenation of Imines via Metal–Organo Cooperative Catalysis

Abstract

The combination of a chiral phosphoric acid with an iridium complex affords a catalyst that allows for highly enantioselective hydrogenation of imines. Mechanistic studies suggest that the hydrogenation proceeds through a ternary transition state at the ­hydride-transfer step, in which the organocatalyst interacts with both the hydride donor and acceptor.

Key words

asymmetric hydrogenation - Brønsted acids - iridium - cooperative catalysis - imines - amines

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