Synlett 2014; 25(13): 1873-1878
DOI: 10.1055/s-0033-1338646
letter
© Georg Thieme Verlag Stuttgart · New York

Metal-Free: A Novel and Efficient Aerobic Oxidation of Primary Amines to Oximes Using N,N′,N″-Trihydroxyisocyanuric Acid and Acetaldoxime as Catalysts in Water

Jiatao Yu
School of Chemical Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Road, Nanjing 210094, P. R. of China   Fax: +86(025)84315030   Email: lumingnjust@163.com
,
Ming Lu*
School of Chemical Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Road, Nanjing 210094, P. R. of China   Fax: +86(025)84315030   Email: lumingnjust@163.com
› Author Affiliations
Further Information

Publication History

Received: 18 March 2014

Accepted after revision: 25 April 2014

Publication Date:
09 July 2014 (online)


Abstract

A general, efficient, and metal-free method for aerobic oxidation of aromatic primary amines to the corresponding oximes catalyzed by N,N′,N″-trihydroxyisocyanuric acid and acetaldoxime with water as solvent is described. This practical method can use air as economic and green oxidant, water as green solvent, and tolerates a wide range of substrates, which can afford the target oximes in moderate to good yields.

Supporting Information

 
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