Synlett 2013; 24(19): 2465-2471
DOI: 10.1055/s-0033-1339875
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© Georg Thieme Verlag Stuttgart · New York

Search for Ideal P-Chiral Phosphorus Ligands for Practical Asymmetric Hydrogenation and Asymmetric Suzuki–Miyaura Coupling

Guodu Liu
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China   Fax: +86(21)54925515   Email: tangwenjun@sioc.ac.cn
,
Guangqing Xu
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China   Fax: +86(21)54925515   Email: tangwenjun@sioc.ac.cn
,
Renshi Luo
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China   Fax: +86(21)54925515   Email: tangwenjun@sioc.ac.cn
,
Wenjun Tang*
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China   Fax: +86(21)54925515   Email: tangwenjun@sioc.ac.cn
› Author Affiliations
Further Information

Publication History

Received: 12 August 2012

Accepted after revision: 03 September 2013

Publication Date:
23 September 2013 (online)

Abstract

The synthesis of P-chiral phosphorus ligands with novel structures is important for the development of efficient asymmetric catalytic transformations. Here, we describe the development of P-chiral phosphorus ligands such as BIBOP, WingPhos, BI-DIME, and 8 in our laboratory. Conformational rigidity, high tunability of electronic and steric properties, and convenient physical properties are the main features of our ligand design. Progress in developing practical asymmetric hydrogenation and asymmetric cross-coupling reactions are discussed.

 
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