Regioselective and Facile Synthesis of 7,9-Dialkyl-8-oxopurines from 7,9-Dialkyl-7,8-dihydropurines: Total Synthesis of Heteromines I and J

Tomáš Tobrman; Dalimil Dvořák

doi:10.1055/s-0033-1340499

Synthesis, Table of Contents

Synthesis 2014; 46(05): 660-668
DOI: 10.1055/s-0033-1340499

paper

Regioselective and Facile Synthesis of 7,9-Dialkyl-8-oxopurines from 7,9-Dialkyl-7,8-dihydropurines: Total Synthesis of Heteromines I and J

Tomáš Tobrman*

Department of Organic Chemistry, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic Fax: +420(220)444288 tomas.tobrman@vscht.cz

,

Dalimil Dvořák

Department of Organic Chemistry, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic Fax: +420(220)444288 tomas.tobrman@vscht.cz

› Author Affiliations

Abstract

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Abstract

A novel protocol for the synthesis of 6-halo-8-oxo-7,8-dihydro-9H-purines based on the oxidation of 7,9-dialkyl-7,8-dihydro-9H-purines has been developed. The presented methodology was used as a key step in the synthesis of heteromines I and J.

Key words

oxidation - reduction - heterocycles - nucleobases - natural product

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References

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