Synthesis, Table of Contents Synthesis 2014; 46(08): 1059-1066DOI: 10.1055/s-0033-1340815 paper © Georg Thieme Verlag Stuttgart · New YorkFacile Synthesis of Spiro[indane-2,1′-pyrrolo[2,1-a]isoquinolines] via Three-Component Reaction of Isoquinolinium Salts, Indane-1,3-dione, and Isatins Authors Author Affiliations Xiao-Hua Wang College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China Fax: +86(514)87975244 Email: cgyan@yzu.edu.cn Chao-Guo Yan* College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China Fax: +86(514)87975244 Email: cgyan@yzu.edu.cn Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Abstract A series of novel 2′-aryl-2′-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2′,3′-dihydro-10b′H-spiro[indene-2,1′-pyrrolo[2,1-a]isoquinoline]-1,3-diones were efficiently synthesized by three-component reactions of in situ generated N-phenacylisoquinolinium bromides with indane-1,3-dione and isatins in ethanol with triethylamine as the base. A domino reaction mechanism for the formation of the spiro compounds was rationally proposed. Key words Key wordsspiro compound - isoquinoline - isatin - indane-1,3-dione - nitrogen ylide - 1,3-cycloaddition Full Text References References 1a Kröhnke F, Zecher W. Angew. Chem. Int. Ed. 1962; 1: 626 1b Kröhnke F. Angew. Chem. Int. Ed. 1963; 2: 225 2 Jacobs J, Van Hende E, Claessens S, De Kimpe N. Curr. Org. Chem. 2011; 15: 1340 3a Wang BX, Zhang XC, Li J, Jiang X, Hu YF, Hu HW. J. 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