Histologie des kutanen Lupus erythematodes

Zusammenfassung

Die histologische Untersuchung von Hautveränderungen spielt eine Schlüsselrolle in der Diagnostik des kutanen Lupus erythematodes (LE). LE zeigt ein breites Spektrum histopathologischer Kriterien, das vom Stadium der Läsionen abhängt. Die hauptsächlichen Subtypen des kutanen LE werden beschrieben und die bedeutendsten Differenzialdiagnosen diskutiert.

Abstract

Histologic examination of lesions plays a key role in the diagnostics of cutaneous lupus erythematosus (LE). LE has a broad spectrum of histopathological signs, which are related to the stages of the lesions. Main subtypes of LE are reported and the most considerable histopathologic differential diagnoses are discussed.

• Literatur

• 1 Sontheimer RD, Thomas JR, Gilliam JN. Subacute cutaneous lupus erythematosus: a cutaneous marker for distinct lupus erythematosus subset. Arch Dermatol 1979; 115: 1409
• 2 Gilliam JN, Sontheimer RD. Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J Am Acad Dermatol 1981; 4: 471
• 3 Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271
• 4 Rothfield N, Sontheimer RD, Bernstein M. Lupus erythematosus: systemic and cutaneous manifestations. Clin Dermatol 2006; 24: 348-362
• 5 Watanabe T, Tsuchida T. Classification of lupus erythematosus based upon cutaneous manifestations. Dermatological, systemic and laboratory findings in 191 patients. Dermatology 1995; 190: 277
• 6 Ackerman AB, Chongchitnant N, Sanchez J et al. Histologic Diagnosis of Inflammatory Skin Diseases. An Algorithmic Method Based on Pattern Analysis. 2nd. ed., chapter 7. Baltimore: Williams & Wilkins; 1997
• 7 Elder D, Elenitsas R, Jaworsky C, Johnson B. Lever’s Histopathology of the Skin. 8ht. ed., chapter 10. Philadelphia: Lippincott-Raven; 1997
• 8 McKee PH. Pathology of the skin with clinical correlations. Chapter 11. London. Lippincott-Gower; 1989
• 9 Bolognia JL, Jorizzo JL, Rapini RP et al. Dermatology. Volume 1, chapter 43. London: Mosby; 2003
• 10 Freedberg IM, Fitzpatrick TB. Fitzpatrick’s Dermatology in General Medicine. 6th. ed., Vol. 2, chapter 171. McGraw-Hill: New York; 2003
• 11 Zedek DC, Smith Jr ET, Hitchcock MG et al. Cutaneous lupus erythematosus simulating squamous neoplasia: the clinicopathologic conundrum and histopathologic pitfalls. J Am Acad Dermatol 2007; 56: 1013-1020
• 12 Bangert JL, Freeman RG, Sontheimer RD et al. Subacute cutaneous lupus erythematosus and discoid lupus erythematosus: comparative histological findings. Arch Dermatol 1984; 120: 332
• 13 Crowson AN, Magro C. The cutaneous pathology of lupus erythematosus: a review. J Cutan Pathol 2001; 28: 1-23
• 14 Jerdan MS, Hood AF, Moore GW et al. Histopathologic comparison of the subsets of lupus erythematosus. Arch Dermatol 1990; 126: 52
• 15 Rowell NR, Swanson-Beck J, Anderson JR. Lupus erythematosus and erythema multiforme-like lesions. Arch Dermatol 1963; 88: 176-180
• 16 Shadid NH, Thissen CA, van Marion AM et al. Lupus erythematosus associated with erythema multiforme: Rowell’s syndrome. Int J Dermatol 2007; 46 (Suppl. 03) 30-32
• 17 Lawrence CM, Marshall TL, Byrne JPH. Lupus erythematosus associated with erythema multiforme-like lesions in identical twins. Br J Dermatol 1982; 107: 349-356
• 18 Fitzgerald EA, Purcell SM, Kantor GR et al. Rowell’s syndrome: report of a case. Journal of the American Academy of Dermatology 1996; 35: 801-803
• 19 Fiallo P, Tagliapietra AG, Santoro G et al. Rowell’s syndrome. International Journal of Dermatology 1995; 34: 635-636
• 20 Parodi A, Drago EF, Varaldo G et al. Rowell’s syndrome. Report of a case. Journal of the American Academy of Dermatology 1989; 21: 374-377
• 21 Gammon WR, Briggaman RA. Bullous SLE: a phenotypically distinctive but immunologically heterogeneous bullous disorder. J Invest Dermatol 1993; 100: 28S-34S
• 22 Yell JA, Allen J, Wojnarowska F et al. Bullous systemic lupus erythematosus: revised criteria for diagnosis. Br J Dermatol 1995; 132: 921
• 23 Kuhn A, Sonntag M, Ruzicka T et al. Histopathologic findings in lupus erythematosus tumidus: review of 80 patients. J Am Acad Dermatol 2003; 48: 901-908
• 24 Alexiades-Armenakas MR, Baldassano M, Bince B et al. Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis. Arthritis Rheum 2003; 49: 494-500
• 25 Vieira V, Del Pozo J, Yebra-Pimentel MT et al. Lupus erythematosus tumidus: a series of 26 cases. Int J Dermatol 2006; 45: 512-17
• 26 Rémy-Leroux V, Léonard F, Lambert D et al. Comparison of histopathologic-clinical characteristics of Jessner’s lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases. J Am Acad Dermatol 2008; 58: 217-23
• 27 Millard LG, Rowell NR. Chilblain lupus erythematosus Hutchinson. Br J Dermatol 1978; 98: 497-506
• 28 Cribier B, Djeridi N, Peltre B et al. A histologic and immunohistochemical study of chilblains. J Am Acad Dermatol 2001; 45: 924-929
• 29 Daldon PE, Macedo de Souza E, Cintra ML. Hypertrophic lupus erythematosus: a clinicopathological study of 14 cases. J Cutan Pathol 2003; 30: 443-448
• 30 Uitto J, Santa-Cruz DJ, Eisen AZ et al. Verrucous lesion in patients with discoid lupus erythematosus. Clinical, histopathological and immunofluorescence studies. Br J Dermatol 1978; 98: 507-520
• 31 Oliver GF, Winkelmann RK, Muller SA. Lichenoid dermatitis: a clinicopathologic and immunopathologic review of sixty-two cases. J Am Acad Dermatol 1989; 21: 284-292
• 32 Peters MS, Su WP. Lupus erythematosus panniculitis. Med Clin North Am 1989; 73: 1113-1126